Milda Girdenyté
PhD student at Department of Pharmacy; Translational PKPD
- E-mail:
- milda.girdenyte@farmaci.uu.se
- Visiting address:
- Biomedicinskt Centrum BMC, Husargatan 3
752 37 Uppsala - Postal address:
- Box 580
751 23 UPPSALA
Download contact information for Milda Girdenyté at Department of Pharmacy; Translational PKPD
- ORCID:
- 0000-0002-3701-3847
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Short presentation
in 2020 I finished and received my MSc in Pharmacy from Vilnius University, Lithuania, and started as a PhD student in 2022 in the Translational Pharmacokinetics and Pharmacodynamics (tPKPD) group. My research project focuses on understanding pharmacokinetic mechanisms of microtubulin-targeting agents (MTAs) in relation to the development and prevention of chemotherapy-induced peripheral neuropathy (CIPN).
Keywords
- adverse event
- bbb
- blood-tissue barriers
- chemotherapy-induced peripheral neuropathy
- cipn
- cns
- dorsal root ganglia
- drug transport
- drug-drug interaction
- microtubulin-targeting agents
- mta
- neuropharmacokinetics
- pharmacokinetics
- pns
- sciatic nerve
- tubulin
Biography
Title: MD in Pharmacy
Position: PhD student
Research area: Translational Pharmacokinetics Pharmacodynamics
Research interest: My research focuses on the better understanding of chemotherapy-induced peripheral neuropathy (CIPN) development and prevention in patients, receiving microtubulin-targeting agents (MTAs) or MTA-antibody-drug-conjugates (ADCs) for their cancer treatment. I focus on the extent of transport to CIPN-specific sites in CNS, PNS and skeletal muscle of unbound MTA concentration. I perform in vivo and in vitro experiments as well as use mathematical modelling approach to systematically evaluate differences between MTAs in relation to their tubulin binding properties.
Collaborations: I work together with Irena Loryan, Lena Friberg, Stina Syvänen, Margareta Hammarlund-Udenaes and Jolanta Gulbinovic (from Vilnius University).
