in 2020 I finished and received my MSc in Pharmacy from Vilnius University, Lithuania, and started as a PhD student in 2022 in the Translational Pharmacokinetics and Pharmacodynamics (tPKPD) group. My research project focuses on understanding pharmacokinetic mechanisms of microtubulin-targeting agents (MTAs) in relation to the development and prevention of chemotherapy-induced peripheral neuropathy (CIPN).
Keywords: pharmacokinetics drug transport neuropharmacokinetics chemotherapy-induced peripheral neuropathy cipn microtubulin-targeting agents mta cns pns blood-tissue barriers tubulin dorsal root ganglia sciatic nerve bbb adverse event drug-drug interaction
Title: MD in Pharmacy
Position: PhD student
Research area: Translational Pharmacokinetics Pharmacodynamics
Research interest: My research focuses on the better understanding of chemotherapy-induced peripheral neuropathy (CIPN) development and prevention in patients, receiving microtubulin-targeting agents (MTAs) or MTA-antibody-drug-conjugates (ADCs) for their cancer treatment. I focus on the extent of transport to CIPN-specific sites in CNS, PNS and skeletal muscle of unbound MTA concentration. I perform in vivo and in vitro experiments as well as use mathematical modelling approach to systematically evaluate differences between MTAs in relation to their tubulin binding properties.
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