I am a researcher in the Pharmacometrics group and work with non-linear mixed effects models, i.e. mathematical models i) describing how concentrations and effects of medicines change over time and vary between patients and ii) used in optimizing drug therapy and drug development.
Keywords: non-linear mixed effects modelling nonmem pharmacokinetics pharmacometrics pharmacodynamics
Dr Siv Jönsson is a senior researcher in the Pharmacometric group within the Department of Pharmacy, Uppsala University, Sweden, headed by Professor Mats O Karlsson. Siv earned an MSc degree in 1988 and has thereafter been working in the pharmacokinetic, pharmacodynamic and pharmacometric areas in three environments: the pharmaceutical industry, the regulatory agency and in academia.
In total 5 years were spent within industry (Kabi Pharmacia, Astra Zeneca) working with clinical pharmacology and pharmacometrics. Furthermore, Siv worked as a pharmacokinetic assessor within the Swedish regulatory authority (Medical Products Agency) in 2 periods (in total 9 years, latest period 2007-2011). Finally, the academic years include her PhD education (PhD obtained in 2004), 2 years as senior lecturer and 8 years as researcher; all these years dealing with methodological and applied pharmacometric projects, where applied projects relate to e.g. renal transplant patients and haemophilia A/B patients.
Siv has published approximately 40 peer-reviewed research articles and book chapters and is currently the co-supervisor of 3 PhD students.
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