Xueliang Ge
Researcher at Department of Cell and Molecular Biology; Molecular Biology
- E-mail:
- xueliang.ge@icm.uu.se
- Visiting address:
- Husargatan 3
752 37 Uppsala - Postal address:
- Box 596
751 24 Uppsala
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Short presentation
Senior Researcher of Molecular Biology. My research is focused on protein synthesis in bacteria include translation initiation, regulation of elongation and termination.
Biography
2014 to now Senior researcher, Dept. of Cell & Molecular biology, BMC Uppsala University, Sweden
2010 to 2014 Post doc. Dept. of Cell & Molecular biology, BMC Uppsala University, Sweden
2007 to 2010 Ph.D. Molecular Cell Biology, Northeast Forestry University, PR China
Research
My research studies mechanisms of protein synthesis in bacteria and the effect of antibiotics on protein translation. I am particularly interested in the research project below.
- The molecular mechanisms of protein synthesis in E. coli and M. smegmatis .
- Design and application of high throughput in vitro reconstituted protein translation system to low molecular weight compound screening.
- Characterization of ribosomal stalk bL12 on protein translation and the development of anti-L12 drug.
- Mechanism of ribosome assembly in E. coli .
- The mechanism of methylation and phosphorylation of translation factor on the regulation of translation in bacteria.
- The mechanism of bacterial environmental stress factors on the regulation of protein translation.
Publications
Recent publications
- Molecular basis of the pleiotropic effects by the antibiotic amikacin on the ribosome (2023)
- Phytochemicals with activity against methicillin-resistant Staphylococcus aureus (2022)
- Uncovering translation roadblocks during the development of a synthetic tRNA (2022)
- GGQ methylation enhances both speed and accuracy of stop codon recognition by bacterial class-I release factors (2021)
- Collateral toxicity limits the evolution of bacterial Release Factor 2 towards total omnipotence (2020)
All publications
Articles
- Molecular basis of the pleiotropic effects by the antibiotic amikacin on the ribosome (2023)
- Phytochemicals with activity against methicillin-resistant Staphylococcus aureus (2022)
- Uncovering translation roadblocks during the development of a synthetic tRNA (2022)
- GGQ methylation enhances both speed and accuracy of stop codon recognition by bacterial class-I release factors (2021)
- Collateral toxicity limits the evolution of bacterial Release Factor 2 towards total omnipotence (2020)
- Selective translation by alternative bacterial ribosomes (2020)
- Loss of a single methylation in 23S rRNA delays 50S assembly at multiple late stages and impairs translation initiation and elongation (2020)
- Inhibition of translation termination by small molecules targeting ribosomal release factors (2019)
- Complementary charge-based interaction between the ribosomal-stalk protein L7/12 and IF2 is the key to rapid subunit association (2018)
- Cryo-EM structure of Mycobacterium smegmatis ribosome reveals two unidentified ribosomal proteins close to the functional centers (2018)
- Experimental Evolution of Escherichia coli Harboring an Ancient Translation Protein (2017)
- Spatial Distribution and Ribosome-Binding Dynamics of EF-P in Live Escherichia coli (2017)
- New melanocortin-like peptide of E. coli can suppress inflammation via the mammalian melanocortin-1 receptor (MC1R) (2017)
- Micrococcin P1-A bactericidal thiopeptide active against Mycobacterium tuberculosis (2016)
- Organization of Ribosomes and Nucleoids in Escherichia coli Cells during Growth and in Quiescence (2014)
- Bacterial ribosome requires multiple L12 dimers for efficient initiation and elongation of protein synthesis involving IF2 and EF-G (2012)
- The extended substrate recognition profile of the dog mast cell chymase reveals similarities and differences to the human chymase (2010)
- An extended C-terminal tail of the ribosomal protein S13 modulates the speed of ribosomal translocation.
