Anna Karin Belfrage
Project Coordinator at Institutionen för läkemedelskemi; Läkemedelsdesign och läkemedelsutveckling
- Telephone:
- +46 18 471 43 36
- E-mail:
- annakarin.belfrage@ilk.uu.se
- Visiting address:
- Biomedicinskt Centrum BMC, Husargatan 3
- Postal address:
- Box 574
751 23 UPPSALA
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Publications
Selection of publications
- Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors (2022)
- ENABLE (2021)
- Pan-NS3 protease inhibitors of hepatitis C virus based on an R3-elongated pyrazinone scaffold (2018)
- INHIBITORS OF METALLO-BETA-LACTAMASES (2018)
- Discovery of pyrazinone based compounds that potently inhibit the drug resistant enzyme variant R155K of the hepatitis C virus NS3 protease (2016)
- Design and Synthesis of Hepatitis C Virus NS3 Protease Inhibitors (2015)
- Efficient and Selective Palladium-Catalysed C-3 Urea Couplings to 3,5-Dichloro-2(1H)-pyrazinones (2015)
- Palladium-Catalyzed Carbonylation of Aryl Iodides with Sulfinamides (2015)
- Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket (2014)
- Binding mode prediction of HCV NS3A protease inhibitors (2012)
- Discovery of 4 '-azido-2 '-deoxy-2 '-C-methyl cytidine and prodrugs thereof (2012)
- Macrocylic inhibitors of hepatitis C virus (2012)
- CYSTEINE PROTEASE INHIBITORS (2011)
- Synthesis and SAR of potent inhibitors of the Hepatitis C virus NS3/4A protease (2010)
- HCV inhibiting macrocyclic phenylcarbamates (2008)
- PYRIMIDINE SUBSTITUTED MACROCYCLIC HCV INHIBITORS (2008)
- MEDI 236-Synthesis and anti-HCV activity of 4'-substituted nucleosides (2006)
- Design and synthesis of potent inhibitors of the malaria aspartyl proteases plasmepsin I and II (2004)
Recent publications
- Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors (2022)
- ENABLE (2021)
- Pan-NS3 protease inhibitors of hepatitis C virus based on an R3-elongated pyrazinone scaffold (2018)
- INHIBITORS OF METALLO-BETA-LACTAMASES (2018)
- Discovery of pyrazinone based compounds that potently inhibit the drug resistant enzyme variant R155K of the hepatitis C virus NS3 protease (2016)
All publications
Articles
- Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors (2022)
- ENABLE (2021)
- Pan-NS3 protease inhibitors of hepatitis C virus based on an R3-elongated pyrazinone scaffold (2018)
- Discovery of pyrazinone based compounds that potently inhibit the drug resistant enzyme variant R155K of the hepatitis C virus NS3 protease (2016)
- Efficient and Selective Palladium-Catalysed C-3 Urea Couplings to 3,5-Dichloro-2(1H)-pyrazinones (2015)
- Palladium-Catalyzed Carbonylation of Aryl Iodides with Sulfinamides (2015)
- Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket (2014)
- Binding mode prediction of HCV NS3A protease inhibitors (2012)
- Discovery of 4 '-azido-2 '-deoxy-2 '-C-methyl cytidine and prodrugs thereof (2012)
- Synthesis and SAR Around the R6 Position of 2(1H)-Pyrazinone Based HCV NS3 Protease Inhibitors (2011)
- Hepatitis C Virus NS3 Protease Inhibitors based on 2(1H)-Pyrazinones (2010)
- Hepatitis C Virus NS3 Protease Inhibitors based on 2(1H)-Pyrazinones (2010)
- Hepatitis C protease inhibitors based on 2(1H)-pyrazinones (2010)
- Synthesis and SAR of potent inhibitors of the Hepatitis C virus NS3/4A protease (2010)
- MEDI 236-Synthesis and anti-HCV activity of 4'-substituted nucleosides (2006)
- Design and synthesis of potent inhibitors of the malaria aspartyl proteases plasmepsin I and II (2004)
- Pyrazinone based hepatitis C virus NS3 protease inhibitors targeting genotype 1a, 3a and the drug-resistant enzyme variant R155K
Books
- Design and Synthesis of Hepatitis C Virus NS3 Protease Inhibitors (2015)
- Synthesis and SAR around the R6 Position of 2(1H)-Pyrazinone Based Hepatitis C (HCV) NS3 Protease Inhibitors (2011)
Patents
