Carina Farah Mugal
Affiliated Researcher at Institutionen för ekologi och genetik; Evolutionsbiologi
- Telephone:
- +46 18 471 64 66
- E-mail:
- Carina.Mugal@ebc.uu.se
- Visiting address:
- Evolutionsbiologiskt Centrum
Norbyvägen 18D
752 36 UPPSALA - Postal address:
- Evolutionsbiologiskt centrum
Norbyvägen 18D
752 36 UPPSALA
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Short presentation
My main research interest lies in understanding patterns of molecular evolution, such as genomic signatures of natural selection, mutation bias and GC-biased gene conversion. In particular, I focus on variation in these patterns among species, across the genome and among different functional elements. In order to explore these questions, I use a multi-disciplinary approach relying on mathematical modeling and comparative genomics, where I primarily use Ficedula flycatchers as a model organism.
Keywords
- gene regulatory evolution
- molecular evolution
- population genomics
- stochastic modeling
- theoretical population genetics
Biography
May 2022 – present
Guest Researcher (10%)
Department of Ecology and Genetics
Uppsala University, Sweden
May 2022 – present
CNRS Researcher
Laboratory of Biometry and Evolutionary Biology (LBBE)
University of Lyon 1, France
July 2017 – April 2022
Researcher
Department of Ecology and Genetics
Uppsala University, Sweden
September 2013 – June 2017
Postdoctoral Researcher
Department of Ecology and Genetics
Uppsala University, Sweden
November 2008 – June 2013
PhD studies in evolutionary genetics
Department of Ecology and Genetics
Uppsala University, Sweden
July 2011 – February 2012
Research internship
Department of Computational Molecular Biology
Max Planck Institute, Berlin
March 2005 – April 2008
Undergraduate studies in theoretical chemistry
Department of Chemistry
University of Graz, Austria
Publications
Selection of publications
- A Nearly Neutral Model of Molecular Signatures of Natural Selection after Change in Population Size (2022)
- Positive selection plays a major role in shaping signatures of differentiation across the genomic landscape of two independent Ficedula flycatcher species pairs (2021)
- Tissue-specific patterns of regulatory changes underlying gene expression differences among Ficedula flycatchers and their naturally occurring F1 hybrids (2020)
- GC-biased gene conversion conceals the prediction of the nearly neutral theory in avian genomes (2019)
- Whole-genome patterns of linkage disequilibrium across flycatcher populations clarify the causes and consequences of fine-scale recombination rate variation in birds (2017)
- The non-equilibrium allele frequency spectrum in a Poisson random field framework (2016)
Recent publications
- The role of recombination dynamics in shaping signatures of direct and indirect selection across the Ficedula flycatcher genome (2024)
- A Nearly Neutral Model of Molecular Signatures of Natural Selection after Change in Population Size (2022)
- Single-Cell Transcriptomics reveals relaxed evolutionary constraint of spermatogenesis in two passerine birds as compared to mammals (2022)
- The Effects of GC-Biased Gene Conversion on Patterns of Genetic Diversity among and across Butterfly Genomes (2021)
- Positive selection plays a major role in shaping signatures of differentiation across the genomic landscape of two independent Ficedula flycatcher species pairs (2021)
All publications
Articles
- The role of recombination dynamics in shaping signatures of direct and indirect selection across the Ficedula flycatcher genome (2024)
- A Nearly Neutral Model of Molecular Signatures of Natural Selection after Change in Population Size (2022)
- Single-Cell Transcriptomics reveals relaxed evolutionary constraint of spermatogenesis in two passerine birds as compared to mammals (2022)
- The Effects of GC-Biased Gene Conversion on Patterns of Genetic Diversity among and across Butterfly Genomes (2021)
- Positive selection plays a major role in shaping signatures of differentiation across the genomic landscape of two independent Ficedula flycatcher species pairs (2021)
- Polymorphism Data Assist Estimation of the Nonsynonymous over Synonymous Fixation Rate Ratio omega for Closely Related Species (2020)
- Tissue-specific patterns of regulatory changes underlying gene expression differences among Ficedula flycatchers and their naturally occurring F1 hybrids (2020)
- GC-biased gene conversion conceals the prediction of the nearly neutral theory in avian genomes (2019)
- Biased Inference of Selection Due to GC-Biased Gene Conversion and the Rate of Protein Evolution in Flycatchers When Accounting for It (2018)
- Sex-biased gene expression, sexual antagonism and levels of genetic diversity in the collared flycatcher (Ficedula albicollis) genome (2018)
- Positive selection on human gamete-recognition genes (2018)
- Genomic distribution and estimation of nucleotide diversity in natural populations (2017)
- Covariation in levels of nucleotide diversity in homologous regions of the avian genome long after completion of lineage sorting (2017)
- Whole-genome patterns of linkage disequilibrium across flycatcher populations clarify the causes and consequences of fine-scale recombination rate variation in birds (2017)
- Recombination Rate Variation Modulates Gene Sequence Evolution Mainly via GC-Biased Gene Conversion, Not Hill-Robertson Interference, in an Avian System (2016)
- Selection on coevolving human gamete recognition genes (2016)
- The non-equilibrium allele frequency spectrum in a Poisson random field framework (2016)
- High-Resolution Mapping of Crossover and Non-crossover Recombination Events by Whole-Genome Re-sequencing of an Avian Pedigree (2016)
- Divergence in gene expression within and between two closely related flycatcher species (2016)
- Linked selection and recombination rate variation drive the evolution of the genomic landscape of differentiation across the speciation continuum of Ficedula flycatchers (2015)
- Evolutionary Consequences of DNA Methylation on the GC Content in Vertebrate Genomes (2015)
- GC-biased gene conversion links the recombination landscape and demography to genomic base composition (2015)
- A high-density linkage map enables a second-generation collared flycatcher genome assembly and reveals the patterns of avian recombination rate variation and chromosomal evolution (2014)
- Why Time Matters (2014)
- Twisted Signatures of GC-Biased Gene Conversion Embedded in an Evolutionary Stable Karyotype (2013)
- Genome-wide analysis in chicken reveals that local levels of genetic diversity are mainly governed by the rate of recombination (2013)
- Substitution rate variation at human CpG sites correlates with non-CpG divergence, methylation level and GC content (2011)
- Conservation of Neutral Substitution Rate and Substitutional Asymmetries in Mammalian Genes (2010)
- Molecular evolution of genes in avian genomes (2010)
- Transcription-induced mutational strand bias and its effect on substitution rates in human genes (2009)
- The role of recombination dynamics in shaping signatures of direct and indirect selection across the Ficedula flycatcher genome
- The combination of HiFi and HiC sequencing technologies enables the investigation of structural variants in speciation of Ficedula flycatchers
- Evidence that genetic drift not adaptation drives fast-Z and large-Z effects in Ficedula flycatchers
- The genomic basis of hybrid male sterility in Ficedula flycatchers
Books
