Bryndis Birnir
Professor at Institutionen för medicinsk cellbiologi
- Visiting address:
- BMC
Husargatan 3
751 23 Uppsala - Postal address:
- Box 571
751 23 UPPSALA
Download contact information for Bryndis Birnir at Institutionen för medicinsk cellbiologi
Professor at Institutionen för medicinsk cellbiologi; Forskargrupp Bryndis Birnir
- E-mail:
- bryndis.birnir@mcb.uu.se
- Visiting address:
- Husargatan 3
751 23 Uppsala - Postal address:
- Box 571
75123 Uppsala
- Academic merits:
- PhD, Associate Professor
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Short presentation
The website of my research group: http://www.neuro.uu.se/forskning/fysiologi/molekylar_fysiologi_och_neurobiologi/
EXODIAB - Excellence Of Diabetes Research in Sweden: http://www.exodiab.se/
Publications
Recent publications
- Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold- Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa (2023)
- Endogenous Levels of Gamma Amino-Butyric Acid Are Correlated to Glutamic-Acid Decarboxylase Antibody Levels in Type 1 Diabetes (2022)
- ZEB2 haploinsufficient Mowat-Wilson syndrome induced pluripotent stem cells show disrupted GABAergic transcriptional regulation and function (2022)
- Monoallelic and bi-allelic variants in NCDN cause neurodevelopmental delay, intellectual disability, and epilepsy (2021)
- Insulin differentially modulates GABA signalling in hippocampal neurons and, in an age-dependent manner, normalizes GABA-activated currents in the tg-APPSwe mouse model of Alzheimer's disease (2021)
All publications
Articles
- Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold- Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa (2023)
- Endogenous Levels of Gamma Amino-Butyric Acid Are Correlated to Glutamic-Acid Decarboxylase Antibody Levels in Type 1 Diabetes (2022)
- ZEB2 haploinsufficient Mowat-Wilson syndrome induced pluripotent stem cells show disrupted GABAergic transcriptional regulation and function (2022)
- Monoallelic and bi-allelic variants in NCDN cause neurodevelopmental delay, intellectual disability, and epilepsy (2021)
- Insulin differentially modulates GABA signalling in hippocampal neurons and, in an age-dependent manner, normalizes GABA-activated currents in the tg-APPSwe mouse model of Alzheimer's disease (2021)
- GABA(A) Receptor-Mediated Currents and Hormone mRNAs in Cells Expressing More Than One Hormone Transcript in Intact Human Pancreatic Islets (2020)
- Tonic GABA-activated synaptic and extrasynaptic currents in dentate gyrus granule cells and CA3 pyramidal neurons along the mouse hippocampal dorsoventral axis (2020)
- Depression, GABA, and Age Correlate with Plasma Levels of Inflammatory Markers (2019)
- Interferon-gamma potentiates GABA(A) receptor-mediated inhibitory currents in rat hippocampal CA1 pyramidal neurons (2019)
- Ataxia in Patients With Bi-Allelic NFASC Mutations and Absence of Full-Length NF186 (2019)
- Transcriptomes of Dravet syndrome iPSC derived GABAergic cells reveal dysregulated pathways for chromatin remodeling and neurodevelopment (2019)
- Gunnar Flemström's legacy in intestinal bicarbonate secretion (2019)
- Expression of calcium release-activated and voltage-gated calcium channels genes in peripheral blood mononuclear cells is altered in pregnancy and in type 1 diabetes (2018)
- GABA Regulates Release of Inflammatory Cytokines From Peripheral Blood Mononuclear Cells and CD4+ T Cells and Is Immunosuppressive in Type 1 Diabetes (2018)
- She is in science to stay! (2018)
- Functional Characterization of Native, High-Affinity GABAA Receptors in Human Pancreatic β Cells (2018)
- Insulin enhances GABAA receptor-mediated inhibitory currents in rat central amygdala neurons (2018)
- Liraglutide modulates GABAergic signaling in rat hippocampal CA3 pyramidal neurons predominantly by presynaptic mechanism (2017)
- AMPA, NMDA and kainate glutamate receptor subunits are expressed in human peripheral blood mononuclear cells (PBMCs) where the expression of GluK4 is altered by pregnancy and GluN2D by depression in pregnant women (2017)
- Characterization of the gamma-aminobutyric acid signaling system in the zebrafish (danio rerio hamilton) central nervous system by reverse transcription-quantitative polymerase chain reaction (2017)
- Normal human CD4+ helper T cells express Kv1.1 voltage-gated K+ channels, and selective Kv1.1 block in T cells induces by itself robust TNFα production and secretion and activation of the NFκB non-canonical pathway (2016)
- Etomidate, propofol and diazepam potentiate GABA-evoked GABAA currents in a cell line derived from Human glioblastoma (2015)
- GABAergic signalling in the immune system (2015)
- The mRNA expression of GABA-A, GABA-B receptor subunits and chloride transporters in peripheral blood mononuclear cells is influenced by gender, pregnancy and depression (2015)
- Expression of GABA receptors subunits in peripheral blood mononuclear cells is gender dependent, altered in pregnancy and modified by mental health (2015)
- Insulin modulates GABAA receptor-mediated neuronal inhibition in rat hippocampus and amygdala (2015)
- GLP-1 and Exendin-4 Transiently Enhance GABA(A) Receptor-Mediated Synaptic and Tonic Currents in Rat Hippocampal CA3 Pyramidal Neurons (2015)
- Modulation of GABAA receptor-mediated synaptic and tonic currents in the rat hippocampus by GLP-1, exendin-4 and diazepam (2015)
- The GLP-1 Receptor Agonist Exendin-4 and Diazepam Differentially Regulate GABAA Receptor-Mediated Tonic Currents in Rat Hippocampal CA3 Pyramidal Neurons (2015)
- Absence of Shb impairs insulin secretion by elevated FAK activity in pancreatic islets (2014)
- GABA-A receptor currents in a cell line (U3047MG) derived from a human glioblastoma tumor are enhanced by etomidate, propofol and diazepam (2014)
- GABA-A receptor subunit expression in human peripheral blood mononuclear cells (2014)
- GABA-A and NMDA receptor subunit mRNA expression is altered in the caudate but not the putamen of the postmortem brains of alcoholics (2014)
- Expression of specific ionotropic glutamate and GABA-A receptor subunits is decreased in central amygdala of alcoholics (2014)
- Selective increases of AMPA, NMDA, and kainate receptor subunit mRNAs in the hippocampus and orbitofrontal cortex but not in prefrontal cortex of human alcoholics (2014)
- Insulin modulates GABA(A) receptor-mediated inhibition in rat amygdala neurons (2014)
- GABA(A) receptor-mediated currents in the hippocampus are transiently enhanced by glucagon-like peptide-1 receptor (GLP-1R) agonists (2014)
- In Intact Islets Interstitial GABA Activates GABA(A) Receptors That Generate Tonic Currents in alpha-Cells (2013)
- GABA is an effective immunomodulatory molecule (2013)
- Monoacylglycerols Activate TRPV1-A Link between Phospholipase C and TRPV1 (2013)
- GABAergic Signaling Is Linked to a Hypermigratory Phenotype in Dendritic Cells Infected by Toxoplasma gondii (2012)
- Selective Changes of GABA(A) Channel Subunit mRNAs in the Hippocampus and Orbitofrontal Cortex but not in Prefrontal Cortex of Human Alcoholics (2012)
- Different subtypes of GABA-A receptors are expressed in human, mouse and rat T lymphocytes (2012)
- GABA-A channel subunit expression in human glioma correlates with tumour histology and clinical outcome (2012)
- GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium (2012)
- GABA-A Channel Subunit Expression in Human Glioma Correlates with Tumor Histology and Clinical Outcome (2012)
- gamma-Aminobutyric acid (GABA) signalling in human pancreatic islets is altered in type 2 diabetes (2012)
- GABA-activated single-channel and tonic currents in rat brain slices (2011)
- Insulin reduces neuronal excitability by turning on GABA(A) channels that generate tonic current (2011)
- Increased GABA(A) channel subunits expression in CD8(+) but not in CD4(+) T cells in BB rats developing diabetes compared to their congenic littermates (2011)
- GABA, a natural immunomodulator of T lymphocytes (2008)
- The impact of sub-cellular location and intracellular neuronal proteins on properties of GABA(A) receptors. (2007)
- Graded response to GABA by native extrasynaptic GABA receptors. (2006)
- Neuron-mediated generation of regulatory T cells from encephalitogenic T cells suppresses EAE. (2006)
- The mechanism of SR95531 inhibition at GABA receptors examined in human alpha1beta1 and alpha1beta1gamma2S receptors. (2005)
- Endogenous unsaturated C18 N-acylethanolamines are vanilloid receptor (TRPV1) agonists. (2005)
- Regulated exocytosis of GABA-containing synaptic-like microvesicles in pancreatic beta-cells. (2004)
- Conductance of recombinant GABA (A) channels is increased in cells co-expressing GABA(A) receptor-associated protein. (2004)
- Penicillin blocks human alpha 1 beta 1 and alpha 1 beta 1 gamma 2S GABAA channels that open spontaneously. (2004)
- Glucose inhibition of glucagon secretion from rat alpha-cells is mediated by GABA released from neighboring beta-cells. (2004)
- Conductance of GABAA channels activated by pentobarbitone in hippocampal neurons from newborn rats. (2003)
- Effects of propofol on GABAA channel conductance in rat-cultured hippocampal neurons. (2003)
- Effects of pentobarbital on GABA-activated currents in acutely-isolated rat dentate gyrus granule neurons. (2003)
- Extrasynaptic GABA(A) channels activated by THIP are modulated by diazepam in CA1 pyramidal neurons in the rat brain hippocampal slice. (2003)
- Evidence for inhibitory effect of the agonist gaboxadol at human alpha 1 beta 2 gamma 2S GABAA receptors. (2003)
- GABA concentration sets the conductance of delayed GABAA channels in outside-out patches from rat hippocampal neurons. (2001)
- Heterogeneity of functional GABA(A) receptors in rat dentate gyrus neurons revealed by a change in response to drugs during the whole-cell current time-course. (2001)
- Bicuculline, pentobarbital and diazepam modulate spontaneous GABA(A) channels in rat hippocampal neurons. (2000)
- Spontaneously opening GABA(A) channels in CA1 pyramidal neurones of rat hippocampus. (2000)
- Mutating the highly conserved second membrane-spanning region 9' leucine residue in the alpha(1) or beta(1) subunit produces subunit-specific changes in the function of human alpha(1)beta(1) gamma-aminobutyric Acid(A) receptors. (2000)
- Pentobarbital modulates gamma-aminobutyric acid-activated single-channel conductance in rat cultured hippocampal neurons. (2000)
- A threonine residue in the M2 region of the beta1 subunit is needed for expression of functional alpha1beta1 GABA(A) receptors. (1999)
- Mutant human alpha(1)beta(1)(T262Q) GABA(A) receptors are directly activated but not modulated by pentobarbital. (1999)
- Two threonine residues in the M2 segment of the alpha 1 beta 1 GABAA receptor are critical for ion channel function. (1998)
- A structural determinant of desensitization and allosteric regulation by pentobarbitone of the GABAA receptor. (1997)
- Nature of the 5' residue in the M2 domain affects function of the human alpha 1 beta 1 GABAA receptor. (1997)
- Hippocampal GABA(A) channel conductance increased by diazepam. (1997)
- Effects of mutating leucine to threonine in the M2 segment of alpha1 and beta1 subunits of GABAA alpha1beta1 receptors. (1996)
- Rapid desensitization of alpha 1 beta 1 GABA A receptors expressed in Sf9 cells under optimized conditions. (1995)
- Characteristics of GABAA channels in rat dentate gyrus. (1994)
- The influence of membrane potential on chloride channels activated by GABA in rat cultured hippocampal neurons. (1993)
- A combination of human alpha 1 and beta 1 subunits is required for formation of detectable GABA-activated chloride channels in Sf9 cells. (1992)
- Voltage-clamp studies of the Na+/glucose cotransporter cloned from rabbit small intestine. (1991)
- Expression and characterization of the intestinal Na+/glucose cotransporter in COS-7 cells. (1990)
- Serum chemistry and evidence of renal failure in the North Atlantic fin whale population. (1986)
- In a cell-type specific manner, high-affinity GABA-A receptors participate in autocrine and paracrine GABA signaling in human pancreatic islets
- GABA, insulin and glucose orchestrate effector functions of human CD4+ T cells
Chapters
