My research is focused on pharmacometrics (PKPD). Topics include optimal experimental design, methodological problems associated with building and evaluating PKPD models, modeling discrete data, and the development and use of PKPD models in a range of therapeutic areas and drug classes including cancer, addiction, PET, progressive disorders, and biologics. I also develop a number of software programs for pharmacometrics.
I teach courses in statistics, drug development, and pharmacometrics.
Keywords: free and open source software pharmacometrics pkpd optimal experimental design optimal design population models nonlinear mixed-effects models
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