Alina Meyer

PhD student at Department of Pharmacy, Drug Delivery

Email:
alina.meyer[AT-sign]farmaci.uu.se
Visiting address:
Biomedicinskt Centrum BMC, Husargatan 3
752 37 Uppsala
Postal address:
Box 580
751 23 UPPSALA

Keywords: pkpd organoids adme drug discovery adpkd drug repurposing kidney disease drugtrain

The general aim of my PhD thesis is to pharmaceutically profile new repurposing candidates for the treatment of the hereditary kidney disease ADPKD. I will perform a series of ADME assays. Then, the intracellular compound concentration and the corresponding pharmacological effect will be investigated using 3D cultured kidney organoids and global proteomics. Furthermore, subcellular target and off-target interaction for lead candidates will be studied and the findings will be combined in a PBPK model.

The project is part of the EU 'DRUGtrain' network.

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Alina Meyer