Douglas Huseby
Researcher at Institutionen för medicinsk biokemi och mikrobiologi; Infektioner och immunitet; Diarmaid Hughes
- Telephone:
- +46 18 471 49 28
- E-mail:
- douglas.huseby@imbim.uu.se
- Visiting address:
- BMC
Husargatan 3
752 37 UPPSALA - Postal address:
- Box 582
751 23 UPPSALA
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Short presentation
My primary research area is the evolution of antibiotic resistance in bacterial populations. I investigate this by evolving bacteria in the presence of antibiotics and then using whole genome sequencing and genetic techniques to reconstruct the evolutionary steps that occurred during the development of resistance. I do this using both existing antibiotics and novel compounds under development. Through this I hope to understand the mechanisms by which bacterial populations develop resistance.
Keywords
- antibiotic
- bacterial genetics
- evolution
- genetics
- whole-genome sequencing
Biography
Publications
Recent publications
- Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold- Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa (2023)
- New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus (2023)
- Evolution of Bacterial Interspecies Hybrids with Enlarged Chromosomes (2022)
- Positive Selection during Niche Adaptation Results in Large-Scale and Irreversible Rearrangement of Chromosomal Gene Order in Bacteria (2022)
- Genetic Architecture and Fitness of Bacterial Interspecies Hybrids (2021)
All publications
Articles
- Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold- Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa (2023)
- New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus (2023)
- Evolution of Bacterial Interspecies Hybrids with Enlarged Chromosomes (2022)
- Positive Selection during Niche Adaptation Results in Large-Scale and Irreversible Rearrangement of Chromosomal Gene Order in Bacteria (2022)
- Genetic Architecture and Fitness of Bacterial Interspecies Hybrids (2021)
- Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis (2021)
- Evaluating the potential efficacy and limitations of a phage for joint antibiotic and phage therapy of Staphylococcus aureus infections (2021)
- Mutant RNA polymerase can reduce susceptibility to antibiotics via ppGpp-independent induction of a stringent-like response (2021)
- Resistance/fitness trade-off is a barrier to the evolution of MarR inactivation mutants in Escherichia coli (2021)
- Phenotypic and genetic barriers to establishment of horizontally transferred genes encoding ribosomal protection proteins (2021)
- Population Bottlenecks Strongly Influence the Evolutionary Trajectory to Fluoroquinolone Resistance in Escherichia coli (2020)
- Antibiotic resistance by high-level intrinsic suppression of a frameshift mutation in an essential gene (2020)
- Structure-activity relationship studies on the inhibition of the bacterial translation of novel Odilorhabdins analogues (2020)
- In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii (2019)
- Effect of aminoacyl-tRNA synthetase mutations on susceptibility to ciprofloxacin in Escherichia coli (2018)
- Methods to determine mutational trajectories after experimental evolution of antibiotic resistance. (2018)
- Imidazopyrazinones (IPYs) (2018)
- Odilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site (2018)
- Muramyl Endopeptidase Spr Contributes to Intrinsic Vancomycin Resistance in Salmonella enterica Serovar Typhimurium (2018)
- Having your cake and eating it - Staphylococcus aureus small colony variants can evolve faster growth rate without losing their antibiotic resistance (2017)
- Alternative Evolutionary Pathways for Drug-Resistant Small Colony Variant Mutants in Staphylococcus aureus (2017)
- Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB) (2017)
- Mutation supply and relative fitness shape the genotypes of ciprofloxacin-resistant Escherichia coli (2017)
- Early-Life Human Microbiota Associated With Childhood Allergy Promotes the T Helper 17 Axis in Mice (2017)
- Ciprofloxacin selects for RNA polymerase mutations with pleiotropic antibiotic resistance effects (2017)
- Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli (2017)
