Taj Muhammad
Researcher at Institutionen för farmaceutisk biovetenskap; Forskning; Farmakognosi
- E-mail:
- taj.muhammad@uu.se
- Visiting address:
- BMC, Husargatan 3
75124 Uppsala - Postal address:
- Box 591
75124 Uppsala
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Research
My PhD work focus on the design and development of peptide antibiotics (based on human host defence peptide, LL-37) and different ways of creating them. In particular, I am interested to make these molecules protease resistant and to characterise structure as well as mode of killing.
Publications
Selection of publications
Recent publications
- Screening for antibacterial and cytotoxic activities of Sri Lankan marine sponges through microfractionation (2024)
- KR-12 derivatives endow nanocellulose with antibacterial and anti-inflammatory properties (2023)
- Epitopes displayed in a cyclic peptide scaffold bind SARS-CoV-2 antibodies (2023)
- A Synthetic Cyclized Antimicrobial Peptide with Potent Effects against Drug-Resistant Skin Pathogens (2023)
- Exploring the limits of cyanobactin macrocyclase PatGmac (2023)
All publications
Articles
- Screening for antibacterial and cytotoxic activities of Sri Lankan marine sponges through microfractionation (2024)
- KR-12 derivatives endow nanocellulose with antibacterial and anti-inflammatory properties (2023)
- Epitopes displayed in a cyclic peptide scaffold bind SARS-CoV-2 antibodies (2023)
- A Synthetic Cyclized Antimicrobial Peptide with Potent Effects against Drug-Resistant Skin Pathogens (2023)
- Exploring the limits of cyanobactin macrocyclase PatGmac (2023)
- Transforming Cross-Linked Cyclic Dimers of KR-12 into Stable and Potent Antimicrobial Drug Leads (2023)
- Screening for Cyclotides in Sri Lankan Medicinal Plants (2023)
- A stable cyclized antimicrobial peptide derived from LL-37 with host immunomodulatory effects and activity against uropathogens (2022)
- Solution NMR and racemic crystallography provide insights into a novel structural class of cyclic plant peptides (2021)
- Backbone Cyclization and Dimerization of LL-37-Derived Peptides Enhance Antimicrobial Activity and Proteolytic Stability (2020)
- Screening for bioactive secondary metabolites in Sri Lankan medicinal plants by microfractionation and targeted isolation of antimicrobial flavonoids from Derris scandens (2020)
- Alanine and Lysine Scans of the LL-37-Derived Peptide Fragment KR-12 Reveal Key Residues for Antimicrobial Activity (2018)
- Chemical Proteomics for Target Discovery of Head-to-Tail Cyclized Mini-Proteins (2017)
- Single-step purification of cyclotides using affinity chromatography (2017)
- Fungi as a source for antibacterial compounds (2016)
- A bioactivity-guided screening of Sri Lankan plants in the search for novel antibacterial and anticancer agents (2016)
- Engineering Of A Minimalized Domain Derived From Human Host Defense Peptide LL-37 Into A Stable And Potent Antimicrobial Drug Lead (2016)
- Engineering of KR-12 (2016)
- Backbone-Cyclized Peptide Dimers Derived from Human Cathelicidin Peptide LL-37 Mediate Potent Antimicrobial Activity (2014)
- Ga-68-Labeling of RGD peptides and biodistribution (2012)
- Immobilisation of semi-pure butelase 1 and its applications to produce head-to-tail cyclic peptides
- Transformation of KR-12 derived cross-linked cyclic dimers into stable and potent antimicrobial drug leads
Books
Conferences
