Michael Hultström
Researcher at Institutionen för medicinsk cellbiologi; Forskargrupp Michael Hultström
- Telephone:
- +46 18 471 41 56
- E-mail:
- michael.hultstrom@mcb.uu.se
- Visiting address:
- BMC
Husargatan 3
751 23 Uppsala - Postal address:
- Box 571
751 23 UPPSALA
Researcher at Institutionen för kirurgiska vetenskaper; Anestesiologi och intensivvård
- Visiting address:
- Akademiska sjukhuset, ingång 70, 1tr
751 85 Uppsala - Postal address:
- Akademiska sjukhuset, ingång 70, 1tr
751 85 UPPSALA
- ORCID:
- 0000-0003-4675-1099
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Short presentation
Researcher in anaesthesiology and intensive care, and kidney- and circulatory physiology. The research program is focused on the development of critical illness and the recovery process afterward with a focus on kidney function.
Keywords
- acute kidney injury
- cardiac function
- covid-19
- fibrosis
- follow-up
- heart failure
- inflammation
- kidney function
- physiology
- sepsis
- shock
- vascular function
Publications
Selection of publications
- COVID-19 patients in intensive care develop predominantly oliguric acute kidney injury (2021)
- Weak anti-SARS-CoV-2 antibody response is associated with mortality in a Swedish cohort of COVID-19 patients in critical care (2020)
- Mannose-Binding Lectin is Associated with Thrombosis and Coagulopathy in Critically Ill COVID-19 Patients (2020)
- Presence of SARS-CoV-2 in urine is rare and not associated with acute kidney injury in critically ill COVID-19 patients (2020)
- Blood type A associates with critical COVID-19 and death in a Swedish cohort (2020)
- Inadequate prophylactic effect of low-molecular weight heparin in critically ill COVID-19 patients (2020)
Recent publications
- Surviving COVID-19 (2024)
- Tumor Predisposing Post-Zygotic Chromosomal Alterations in Bladder Cancer-Insights from Histologically Normal Urothelium (2024)
- Physical activity is associated with a lower risk of contracting and dying in infection and sepsis (2024)
- In Vivo Visualization and Quantification of Neutrophil Elastase in Lungs of COVID-19 Patients (2023)
- Immuno-Modulatory Effects of Dexamethasone in Severe COVID-19 (2023)
All publications
Articles
- Surviving COVID-19 (2024)
- Tumor Predisposing Post-Zygotic Chromosomal Alterations in Bladder Cancer-Insights from Histologically Normal Urothelium (2024)
- Physical activity is associated with a lower risk of contracting and dying in infection and sepsis (2024)
- In Vivo Visualization and Quantification of Neutrophil Elastase in Lungs of COVID-19 Patients (2023)
- Immuno-Modulatory Effects of Dexamethasone in Severe COVID-19 (2023)
- Central nervous system biomarkers GFAp and NfL associate with post-acute cognitive impairment and fatigue following critical COVID-19 (2023)
- Sustained IFN signaling is associated with delayed development of SARS-CoV-2-specific immunity (2023)
- Intermittent thoracic resuscitative endovascular balloon occlusion of the aorta improves renal function compared to 60 min continuous application after porcine class III hemorrhage (2023)
- HLA allele-calling using whole-exome sequencing identifies 129 novel associations in 11 autoimmune diseases: a multi-ancestry analysis in the UK Biobank (2023)
- Increasing serum iron levels and their role in the risk of infectious diseases (2023)
- Postoperative acute kidney injury after volatile or intravenous anesthesia (2023)
- Plasma cytokine levels in spinal surgery with sevoflurane or total intravenous propofol anesthesia (2023)
- Health-related quality of life after surviving intensive care for COVID-19 (2023)
- Analysis of Calprotectin as an Early Marker of Infections Is Economically Advantageous in Intensive Care-Treated Patients (2023)
- Antibiotic use during coronavirus disease 2019 intensive care unit shape multidrug resistance bacteriuria (2023)
- Estimated glomerular filtration rates are higher when creatinine-based equations are compared with a cystatin C-based equation in coronavirus disease 2019 (2023)
- Poor long-term recovery after critical COVID-19 during 12 months longitudinal follow-up (2023)
- Infectious SARS-CoV-2 is rarely present in the nasopharynx samples collected from Swedish hospitalized critically ill COVID-19 patients (2023)
- Diagnostic Values of METTL1-Related Genes and Immune Characteristics in Systemic Lupus Erythematosus (2023)
- Global Burden of Cardiovascular Diseases and Risks, 1990-2022 (2023)
- Strain on the ICU resources and patient outcomes in the COVID-19 pandemic (2023)
- Prior physical illness predicts death better than acute physiological derangement on intensive care unit admission in COVID-19 (2023)
- Proteome-wide Mendelian randomization implicates nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity (2023)
- A second update on mapping the human genetic architecture of COVID-19 (2023)
- A comparison of impact of comorbidities and demographics on 60-day mortality in ICU patients with COVID-19, sepsis and acute respiratory distress syndrome (2022)
- The Evolution of Blood Cell Phenotypes, Intracellular and Plasma Cytokines and Morphological Changes in Critically Ill COVID-19 Patients (2022)
- Loss of Y in leukocytes as a risk factor for critical COVID-19 in men (2022)
- Exome-wide association study to identify rare variants influencing COVID-19 outcomes (2022)
- Neutrophil extracellular traps promote cancer-associated inflammation and myocardial stress. (2022)
- Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity (2022)
- The extent of neuroradiological findings in COVID-19 shows correlation with blood biomarkers, Glasgow coma scale score and days in intensive care (2022)
- Deletion of Notch3 Impairs Contractility of Renal Resistance Vessels Due to Deficient Ca2+ Entry (2022)
- Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19 (2022)
- Angiopoietin-2 Inhibition of Thrombomodulin-Mediated Anticoagulation (2022)
- Limitations of the ARDS criteria during high-flow oxygen or non-invasive ventilation (2022)
- Dehydration is associated with production of organic osmolytes and predicts physical long-term symptoms after COVID-19 (2022)
- Impaired Antibody Response Is Associated with Histone-Release, Organ Dysfunction and Mortality in Critically Ill COVID-19 Patients. (2022)
- Differential Bias for Creatinine- and Cystatin C- Derived Estimated Glomerular Filtration Rate in Critical COVID-19. (2022)
- Plasma Leptin Is Increased in Intensive Care Patients with COVID-19—An Investigation Performed in the PronMed-Cohort (2022)
- Shrunken Pore Syndrome Is Frequently Occurring in Severe COVID-19 (2022)
- Decreased renal perfusion during acute kidney injury in critical COVID-19 assessed by magnetic resonance imaging (2022)
- How the Innate Immune System of the Blood Contributes to Systemic Pathology in COVID-19-Induced ARDS and Provides Potential Targets for Treatment (2022)
- A first update on mapping the human genetic architecture of COVID-19 (2022)
- Chest dual-energy CT to assess the effects of steroids on lung function in severe COVID-19 patients (2022)
- Intensive care-treated COVID-19 patients' perception of their illness and remaining symptoms. (2022)
- Tacrolimus Causes Hypertension by Increasing Vascular Contractility via RhoA (Ras Homolog Family Member A)/ROCK (Rho-Associated Protein Kinase) Pathway in Mice (2022)
- Estimated Global Proportions of Individuals With Persistent Fatigue, Cognitive, and Respiratory Symptom Clusters Following Symptomatic COVID-19 in 2020 and 2021 (2022)
- A global systematic analysis of the occurrence, severity, and recovery pattern of long COVID in 2020 and 2021 (2022)
- The swedish covid-19 intensive care cohort (2021)
- Plasma endostatin correlates with hypoxia and mortality in COVID-19-associated acute respiratory failure (2021)
- Systemic Human Neutrophil Lipocalin Associates with Severe Acute Kidney Injury in SARS-CoV-2 Pneumonia (2021)
- Increased levels of plasma cytokines and correlations to organ failure and 30-day mortality in critically ill Covid-19 patients (2021)
- Impaired diffusing capacity for carbon monoxide is common in critically ill Covid-19 patients at four months post-discharge (2021)
- Critical illness polyneuropathy, myopathy and neuronal biomarkers in COVID-19 patients (2021)
- Point of care ultrasound screening for deep vein thrombosis in critically ill COVID-19 patients, an observational study (2021)
- Case report (2021)
- Urinary cytokines correlate with acute kidney injury in critically ill COVID-19 patients (2021)
- Evolution of NETosis markers and DAMPs have prognostic value in critically ill COVID-19 patients (2021)
- Histone H3 Cleavage in Severe COVID-19 ICU Patients. (2021)
- Elevated Angiopoietin-2 inhibits thrombomodulin-mediated anticoagulation in critically ill COVID-19 patients (2021)
- Severe acute kidney injury associated with progression of chronic kidney disease after critical COVID-19 (2021)
- Surgical trauma is associated with renal immune cell activation in rats (2021)
- The impact of viremia on organ failure, biomarkers and mortality in a Swedish cohort of critically ill COVID-19 patients (2021)
- High expression of neutrophil and monocyte CD64 with simultaneous lack of upregulation of adhesion receptors CD11b, CD162, CD15, CD65 on neutrophils in severe COVID-19 (2021)
- The Outcome of Critically Ill COVID-19 Patients Is Linked to Thromboinflammation Dominated by the Kallikrein/Kinin System (2021)
- COVID-19 patients in intensive care develop predominantly oliguric acute kidney injury (2021)
- The contribution of plasma urea to total osmolality during iatrogenic fluid reduction in critically ill patients (2021)
- A quantitative analysis of extension and distribution of lung injury in COVID-19 (2021)
- ECG pathology and its association with death in critically ill COVID-19 patients, a cohort study (2021)
- Soluble TNF receptors predict acute kidney injury and mortality in critically ill COVID-19 patients (2021)
- Plasma hyaluronan, hyaluronidase activity and endogenous hyaluronidase inhibition in sepsis (2021)
- Plasma Hyaluronan Decreases During ICU Stay in COVID-19 Survivors but Not inNon-Survivor (2021)
- A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity (2021)
- Mapping the human genetic architecture of COVID-19 (2021)
- Weak anti-SARS-CoV-2 antibody response is associated with mortality in a Swedish cohort of COVID-19 patients in critical care (2020)
- Mannose-Binding Lectin is Associated with Thrombosis and Coagulopathy in Critically Ill COVID-19 Patients (2020)
- Presence of SARS-CoV-2 in urine is rare and not associated with acute kidney injury in critically ill COVID-19 patients (2020)
- Blood type A associates with critical COVID-19 and death in a Swedish cohort (2020)
- Hyperreninemia and low total body water may contribute to acute kidney injury in COVID-19 patients in intensive care (2020)
- Optimal cutting temperature medium embedding and cryostat sectioning are valid for cardiac myofilament function assessment (2020)
- Patient satisfaction with continuous epidural analgesia after major surgical procedures at a Swedish University hospital (2020)
- Analgesic effects of dexmedetomidine and remifentanil on periprocedural pain during percutaneous ablation of renal carcinoma (2020)
- Inadequate prophylactic effect of low-molecular weight heparin in critically ill COVID-19 patients (2020)
- Quantitative trait loci associated with angiotensin II and high-salt diet induced acute decompensated heart failure in Balb/CJ mice (2019)
- Time course of decompensation after angiotensin II and high-salt diet in Balb/CJ mice suggests pulmonary hypertension-induced cardiorenal syndrome (2019)
- NFAT5 regulates renal gene expression in response to angiotensin II through Annexin-A2-mediated posttranscriptional regulation in hypertensive rats (2019)
- Angiotensin II and salt-induced decompensation in Balb/CJ mice is aggravated by fluid retention related to low oxidative stress (2019)
- ADAMTS13 protects mice against renal ischemia-reperfusion injury by reducing inflammation and improving endothelial function (2019)
- Comparison of acute kidney injury of different aetiology reveals in-common mechanisms of tissue damage (2018)
- Losartan does not decrease renal oxygenation and norepinephrine effects in rats after resuscitated hemorrhage. (2018)
- ICU mortality and variables associated with ICU survival in Poland (2018)
- Osthole Ameliorates Renal Fibrosis in Mice by Suppressing Fibroblast Activation and Epithelial-Mesenchymal Transition (2018)
- Genetic association of oxidative stress and fluid accumulation makes Balb/CJ mice more sensitive to decompensated heart failure (2017)
- Case of subdural hematoma after labor epidural (2017)
- In-common molecular pathway for six different etiologies of acute kidney injury (2017)
- Norepinephrine effects are not affected by Losartan in rats after resuscitated haemorrhage (2017)
- Mortality rate in Polish intensive care units is lower than predicted according to the APACHE II scoring system. (2017)
- Macrophage infiltration in the kidney after prolonged surgery with anesthesia (2017)
- c-Jun N-terminal Kinase mediates prostaglandin-induced sympathoexcitation in rats with chronic heart failure by reducing GAD1 and GABRA1 expression (2017)
- Comparison of ICU outcomes in Poland to other European countries (2017)
- Mortality rate is higher in Polish intensive care units than in other European countries (2017)
- Unilateral renal ischemia in rats induces a rapid secretion of inflammatory markers to renal lymph and increased peritubular capillary permeability (2016)
- Increased hydrogen peroxide impairs angiotensin II contractions of afferent arterioles in mice after renal ischaemia-reperfusion injury (2016)
- Renal oxygenation during haemorrhage is not aggravated by angiotensin II AT1-receptor blockade (2016)
- Sympathoexcitation in Rats With Chronic Heart Failure Depends on Homeobox D10 and MicroRNA-7b Inhibiting GABBR1 Translation in Paraventricular Nucleus (2016)
- LACK OF EFFECT OF DIETARY NITRATE IN ELITE ATHLETES MAY BE DUE TO DILATION OF NON-PRIORITIZED VASCULAR BEDS (2015)
- Caloric restriction reduces age-related but not all-cause mortality (2015)
- Commentaries on Viewpoint (2015)
- C57BL/6J mice are resistant to cardiorenal syndrome during high-salt and Angiotensin II treatment compared to Balb/c because of higher oxidative stress (2015)
- Noradrenaline enhances angiotensin II responses via p38 MAPK activation after hypoxia/re-oxygenation in renal interlobar arteries (2015)
- Angiotensin II AT1-receptor blockade using Losartan does not impair renal oxygenation following hemorrhage (2015)
- Identification of a common molecular pathway in hypertensive renal damage (2015)
- Matrix Metalloproteinase-2 Knockout and Heterozygote Mice Are Protected from Hydronephrosis and Kidney Fibrosis after Unilateral Ureteral Obstruction (2015)
- Distinct protein signature of hypertension-induced damage in the renal proteome of the two-kidney, one-clip rat model (2015)
- Ingrid Toft (June 2, 1959-April 26, 2014) (2014)
- Validation of Uromodulin as a Candidate Gene for Human Essential Hypertension (2014)
- Nucleic acid binding of annexin A2 is regulated through angiotensin II/AT1 signaling in kidneys of hypertensive rats (2014)
- Intradermal Insulin Delivery (2014)
- Lower oxidative stress is associated with angiotensin II and salt-induced acute cardiorenal failure in BalbC mice but not C57Black6 (2014)
- Renal neurohormonal regulation in heart failure decompensation (2014)
- DIFFERENTIAL PROTEOMICS OF EXPERIMENTAL HYPERTENSIVE RENAL DISEASE REVEALS DISTINCT PROTEIN SIGNATURES AND PERIOSTIN AS A DAMAGE MARKER (2014)
- Sex-specific prevalence of fatty liver disease and associated metabolic factors in Wuhan, south central China (2014)
- Attenuated contractility in afferent arterioles during development of proteinuria in two-kidney, one-clip hypertensive rats (2013)
- Proteomic analysis of outer and juxtamedullary cortex of non-clipped kidneys in 2K1C hypertensive rats (2013)
- Nitric oxide in afferent arterioles after uninephrectomy depends on extracellular L-arginine (2013)
- Neurohormonal interactions on the renal oxygen delivery and consumption in haemorrhagic shock-induced acute kidney injury (2013)
- Arterial damage precedes the development of interstitial damage in the nonclipped kidney of two-kidney, one-clip hypertensive rats (2013)
- Prevalence and associated metabolic factors of fatty liver disease in the elderly (2013)
- Development of structural kidney damage in spontaneously hypertensive rats (2012)
- Njurarnas betydelse vid utveckling av essentiell hypertoni (2012)
- Collagen-binding proteins in age-dependent changes in renal collagen turnover (2012)
- Renal extracellular matrix in three rat-models of hypertensive kidney damage (2012)
- MMP2 deficient mice are protected from hydronephrosis after unilateral urethral obstruction (2012)
- Nyrenes betydning ved utvikling av essensiell hypertensjon (2011)
- Bjarne Magnus Iversen (30 March 1942 – 5 August 2011) (2011)
- Afferent arteriolopathy and glomerular collapse but not segmental sclerosis induce tubular atrophy in old spontaneously hypertensive rats (2011)
- Angiotensin II-induced contraction is attenuated by nitric oxide in afferent arterioles from the nonclipped kidney in 2K1C (2009)
- Norepinephrine increases calcium sensitivity of mouse afferent arteriole, thereby enhancing angiotensin II-mediated vasoconstriction (2009)
- Nitrogen oxyd (NO) og nyrearteriestenose (2008)
- Moderate hypothermia induces a preferential increase in pancreatic islet blood flow in anesthetized rats (2007)
- Adenosine triphosphate increases the reactivity of the afferent arteriole to low concentrations of norepinephrine (2007)
- One-year functional recovery from severe Covid-19 is severely affected in the Swedish intensive care and hospital admitted working age cohort
- Plasma expansion and renal perfusion in critical COVID-19 with AKI: a prospective case control study
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