Lena Kjellén
Professor at Institutionen för medicinsk biokemi och mikrobiologi; Cancer; Lena Kjellén
- Telephone:
- +46 18 471 42 17
- E-mail:
- Lena.Kjellen@imbim.uu.se
- Visiting address:
- BMC
Husargatan 3
752 37 UPPSALA - Postal address:
- Box 582
751 23 UPPSALA
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Publications
Recent publications
- Mapping the Human Chondroitin Sulfate Glycoproteome Reveals an Unexpected Correlation Between Glycan Sulfation and Attachment Site Characteristics (2023)
- Landscape of mast cell populations across organs in mice and humans (2023)
- Chondroitin/dermatan sulfate glycosyltransferase genes are essential for craniofacial development (2022)
- A dominant negative splice variant of the heparan sulfate biosynthesis enzyme NDST1 reduces heparan sulfate sulfation (2022)
- Heparan Sulfate Biosynthesis in Zebrafish (2021)
All publications
Articles
- Mapping the Human Chondroitin Sulfate Glycoproteome Reveals an Unexpected Correlation Between Glycan Sulfation and Attachment Site Characteristics (2023)
- Landscape of mast cell populations across organs in mice and humans (2023)
- Chondroitin/dermatan sulfate glycosyltransferase genes are essential for craniofacial development (2022)
- A dominant negative splice variant of the heparan sulfate biosynthesis enzyme NDST1 reduces heparan sulfate sulfation (2022)
- Heparan Sulfate Biosynthesis in Zebrafish (2021)
- Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate (2020)
- Establishment and characterization of Drosophila cell lines mutant for heparan sulfate modifying enzymes (2019)
- Mitogen-Activated Protein Kinase Signaling Regulates Proteoglycan Composition of Mast Cell Secretory Granules (2018)
- Specificity of glycosaminoglycan-protein interactions (2018)
- Expanding the chondroitin glycoproteome of Caenorhabditis elegans (2018)
- Separation and Purification of Glycosaminoglycans (GAGs) from Caenorhabditis elegans (2017)
- Identification of novel chondroitin sulfate sulfotransferases and proteoglycan core proteins in the nematode C. elegans (2017)
- Copper Regulates Maturation and Expression of an MITF (2017)
- Heparanase confers a growth advantage to differentiating murine embryonic stem cells, and enhances oligodendrocyte formation. (2017)
- Versican accumulates in vascular lesions in pulmonary arterial hypertension (2016)
- NDST2 (N-Deacetylase/N-Sulfotransferase-2) Enzyme Regulates Heparan Sulfate Chain Length (2016)
- Altered heparan sulfate structure in Glce(-/-) mice leads to increased Hedgehog signaling in endochondral bones (2016)
- Nematodes join the family of chondroitin sulfate-synthesizing organisms (2016)
- Metastasis Stimulation by Hypoxia and Acidosis-Induced Extracellular Lipid Uptake Is Mediated by Proteoglycan-Dependent Endocytosis (2016)
- Serglycin proteoglycans limit enteropathy in Trichinella spiralis-infected mice (2016)
- The Ndst Gene Family in Zebrafish (2015)
- Identification of Chondroitin Sulfate Linkage Region Glycopeptides Reveals Prohormones as a Novel Class of Proteoglycans (2015)
- Profiling sulfation/epimerization pattern of full-length heparan sulfate by NMR following cell culture C-13-glucose metabolic labeling (2015)
- Ctr2 Regulates Mast Cell Maturation by Affecting the Storage and Expression of Tryptase and Proteoglycans (2015)
- Mast Cell Chymase Degrades the Alarmins Heat Shock Protein 70, Biglycan, HMGB1, and Interleukin-33 (IL-33) and Limits Danger-induced Inflammation (2014)
- Expression of chondroitin/dermatan sulfate glycosyltransferases during early zebrafish development (2013)
- Distorted Secretory Granule Composition in Mast Cells with Multiple Protease Deficiency (2013)
- MicroRNA-24 Suppression of N-Deacetylase/N-Sulfotransferase-1 (NDST1) Reduces Endothelial Cell Responsiveness to Vascular Endothelial Growth Factor A (VEGFA) (2013)
- Pathophysiology of heparan sulphate (2013)
- Dimerized Glycosaminoglycan Chains Increase FGF Signaling during Zebrafish Development (2013)
- Heparin biosynthesis (2012)
- Undersulfation of Heparan Sulfate Restricts Differentiation Potential of Mouse Embryonic Stem Cells (2012)
- Glycobiology (2012)
- Heparan Sulfate Biosynthesis (2012)
- Functional Overlap Between Chondroitin and Heparan Sulfate Proteoglycans During VEGF-Induced Sprouting Angiogenesis (2012)
- Heparan Sulfate Biosynthesis Enzymes in Embryonic Stem Cell Biology (2012)
- Lowered Expression of Heparan Sulfate/Heparin Biosynthesis Enzyme N-Deacetylase/N-Sulfotransferase 1 Results in Increased Sulfation of Mast Cell Heparin (2011)
- Mucopolysaccharidosis Type I, Unique Structure of Accumulated Heparan Sulfate and Increased N-Sulfotransferase Activity in Mice Lacking alpha-L-iduronidase (2011)
- Mesomelia-Synostoses Syndrome Results from Deletion of SULF1 and SLCO5A1 Genes at 8q13 (2010)
- Mice deficient in heparan sulfate N-deacetylase/N-sulfotransferase 1. (2010)
- Heparin/heparan sulfate biosynthesis (2008)
- Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organization (2008)
- Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation (2008)
- Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular development (2007)
- Contribution of EXT1, EXT2, and EXTL3 to heparan sulfate chain elongation (2007)
- Heparan sulfate in trans potentiates VEGFR-mediated angiogenesis (2006)
- Heparan sulphate requirement in platelet-derived growth factor B-mediated pericyte recruitment (2006)
- Enzymatically active N-deacetylase/N-sulfotransferase-2 is present in liver but does not contribute to heparan sulfate N-sulfation (2006)
- No change in glomerular heparan sulfate structure in early human and experimental diabetic nephropathy (2006)
- Heparan sulfate synthesized by mouse embryonic stem cells deficient in NDST1 and NDST2 is 6-O-sulfated but contains no N-sulfate groups (2004)
- Heparan sulfate synthesized by mouse embryonic stem cells deficient in NDST1 and NDST2 is 6-O-sulfated but contains no N-sulfate groups. (2004)
- Neurogenic inflammation in mice deficient in heparin-synthesizing enzyme. (2004)
- Heparan sulfate structure in mice with genetically modified heparan sulfate production. (2004)
- Distinct effects on heparan sulfate structure by different active site mutations in NDST-1 (2003)
- Antibody-based assay for N-deacetylase activity of heparan sulfate/heparinN-deacetylase/N-sulfotransferase (NDST): novel characteristics of NDST-1and -2. (2003)
- Heparan sulfate and development (2002)
- Defective heparan sulfate biosynthesis and neonatal lethality in mice lacking N-deacetylase/N-sulfotransferase-1 (2000)
- Abnormal mast cells in mice deficient in a heparin-sythesizing enzyme (1999)
- Biosynthesis of heparin / heparan sulfate (1997)
- More to "heparin" than anticoagulation (1994)
- Heparan sulfate biosynthesis: Characterization of an NDST1 splice variant
- Heparan sulfate biosynthesis in zebrafish
- Heparan sulfate biosynthesis
- Lack of both lethality and defective in vitro differentiation of embryonic stem cells N-deacetylase/N-sulfotransferase 1 and 2 causes early embryonic
- Cell surface mast cell proteoglycans identified as heparin-substituted syndecan-2
- Divergent effects of heparan sulfate/heparin biosynthesis enzymes N-deacetylase/N-sulfotransferase 1 and 2 on Mast cell development
- Impaired mast cell development in N-deacetylase/N-sulfotransferase deficient embryonic stem cells
- Mice lacking N-deacetylase/N-sulfotransferase 1 and 2 are defective in early postimplantation development
- Heparan sulfate expression is critical in vascular development
- In vivo regulation of liver heparan sulfate biosynthesis in NDST1 and NDST2 deficient mice
- Heparan sulfate biosynthesis: PAPS regulates NDST-mediated formation of N-sulfated domains
- EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation
- Several processes in skeletal development are affected by altered heparan sulfate structure
- Effects of wild-type and mutant EXT2 on heparan sulfate chain length
