Maria Selmer
Professor i biologi, särskilt strukturbiologi. Docent vid Institutionen för cell- och molekylärbiologi; Strukturbiologi
- Telefon:
- 018-471 41 77
- Mobiltelefon:
- 070-167 97 61
- E-post:
- maria.selmer@icm.uu.se
- Besöksadress:
- Husargatan 3
752 37 Uppsala - Postadress:
- Box 596
75124 Uppsala
Professor vid Institutionen för cell- och molekylärbiologi; Uppsala RNA Research Centre - URRC
- Telefon:
- 018-471 41 77
- Mobiltelefon:
- 070-167 97 61
- E-post:
- Maria.Selmer@icm.uu.se
- Besöksadress:
- Husargatan 3
752 37 Uppsala - Postadress:
- Box 596
751 24 Uppsala
Mer information visas för dig som medarbetare om du loggar in.
Forskning
Denna text finns inte på svenska, därför visas den engelska versionen.
The Selmer lab uses integrated structural biology in two different areas, protein synthesis coupled to antibiotic resistance and evolution of protein structure and function. Our research is described here.
Publikationer
Urval av publikationer
- Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family (2021)
- Structure and Characterization of Phosphoglucomutase 5 from Atlantic and Baltic Herring (2020)
- Structural Recognition of Spectinomycin by Resistance Enzyme ANT(9) from Enterococcus faecalis (2020)
- Structure and kinetics of indole-3-glycerol phosphate synthase from Pseudomonas aeruginosa (2020)
- Crystal structure of ErmE-23S rRNA methyltransferase in macrolide resistance (2019)
- A bacteriophage enzyme induces bacterial metabolic perturbation that confers a novel promiscuous function (2018)
- Structural mechanism of AadA, a dual specificity aminoglycoside adenylyltransferase from Salmonella enterica (2018)
- Structural and functional innovations in the real-time evolution of new (βα)8 barrel enzymes (2017)
- Two-step Ligand Binding in a (βα)8 Barrel Enzyme (2015)
- Structure and function of FusB (2012)
- Mechanism of Elongation Factor-G-mediated Fusidic Acid Resistance and Fitness Compensation in Staphylococcus aureus (2012)
- Crystal structure of RlmM, the 2'O-ribose methyltransferase for C2498 of Escherichia coli 23S rRNA (2012)
- Ribosome engineering to promote new crystal forms (2012)
- The structure of the ribosome with elongation factor G trapped in the posttranslocational state (2009)
- Structures of tRNAs with an expanded anticodon loop in the decoding center of the 30S ribosomal subunit (2007)
Senaste publikationer
- Phage T3 overcomes the BREX defense through SAM cleavage and inhibition of SAM synthesis by SAM lyase (2023)
- Structural Consequences of Deproteinating the 50S Ribosome (2022)
- Structures and kinetics of Thermotoga maritima MetY reveal new insights into the predominant sulfurylation enzyme of bacterial methionine biosynthesis (2021)
- Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family (2021)
- Oligomerization and characteristics of phosphoenolpyruvate carboxylase in Synechococcus PCC 7002 (2020)
Alla publikationer
Artiklar
- Phage T3 overcomes the BREX defense through SAM cleavage and inhibition of SAM synthesis by SAM lyase (2023)
- Structural Consequences of Deproteinating the 50S Ribosome (2022)
- Structures and kinetics of Thermotoga maritima MetY reveal new insights into the predominant sulfurylation enzyme of bacterial methionine biosynthesis (2021)
- Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family (2021)
- Oligomerization and characteristics of phosphoenolpyruvate carboxylase in Synechococcus PCC 7002 (2020)
- Structure and Characterization of Phosphoglucomutase 5 from Atlantic and Baltic Herring (2020)
- Structural Recognition of Spectinomycin by Resistance Enzyme ANT(9) from Enterococcus faecalis (2020)
- Structure and kinetics of indole-3-glycerol phosphate synthase from Pseudomonas aeruginosa (2020)
- Crystal structure of ErmE-23S rRNA methyltransferase in macrolide resistance (2019)
- A bacteriophage enzyme induces bacterial metabolic perturbation that confers a novel promiscuous function (2018)
- Structural mechanism of AadA, a dual specificity aminoglycoside adenylyltransferase from Salmonella enterica (2018)
- Structural and functional innovations in the real-time evolution of new (βα)8 barrel enzymes (2017)
- Two proofreading steps amplify the accuracy of genetic code translation (2016)
- Structure of AadA from Salmonella enterica (2015)
- Two-step Ligand Binding in a (βα)8 Barrel Enzyme (2015)
- Resistance to beta-Lactam Antibiotics Conferred by Point Mutations in Penicillin-Binding Proteins PBP3, PBP4 and PBP6 in Salmonella enterica (2014)
- Investigating Ribosome Conformations with Multi-Resolution Modeling (2014)
- Energetic pathway sampling in a protein interaction domain (2013)
- Structural and functional insights into the molecular mechanism of rRNA m6A methyltransferase RlmJ (2013)
- Purification, crystallization and preliminary X-ray diffraction analysis of the 23S rRNA methyltransferase RlmJ from Escherichia coli (2013)
- Structure and function of FusB (2012)
- Tolerance of Protein Folding to a Circular Permutation in a PDZ Domain (2012)
- Mechanism of Elongation Factor-G-mediated Fusidic Acid Resistance and Fitness Compensation in Staphylococcus aureus (2012)
- Crystal structure of RlmM, the 2'O-ribose methyltransferase for C2498 of Escherichia coli 23S rRNA (2012)
- Ribosome engineering to promote new crystal forms (2012)
- Staphylococcus aureus elongation factor G - structure and analysis of a target for fusidic acid (2010)
- The plastic energy landscape of protein folding (2010)
- The structure of the ribosome with elongation factor G trapped in the posttranslocational state (2009)
- Exit biology (2008)
- Structures of tRNAs with an expanded anticodon loop in the decoding center of the 30S ribosomal subunit (2007)
- Crystal structure of the ribosome recycling factor bound to the ribosome (2007)
- Structure of a phage-encoded SAMase enzyme provides insights in substrate binding and mechanism
- Substrate recognition by 23S RNA methyltransferase RlmF
- The compensatory mechanism of a naturally-evolved E167K RF2 counteracting the loss of RF1 in bacteria
- Structure of a phage-encoded SAM hydrolase enzyme provides insights in substrate binding and catalysis
- Structure and substrate ambiguity of TrpC from Pseudomonas aeruginosa
