Håkan Aldskogius
Professor emer. i med. strukturbiologi vid Institutionen för immunologi, genetik och patologi; Forskningsprogram: Genomik och Neurobiologi; Forskargrupp Elena Kozlova
- Telefon:
- 018-471 41 11
- E-post:
- hakan.aldskogius@igp.uu.se
- Besöksadress:
- BMC
Husargatan 3
751 23 UPPSALA - Postadress:
- IGP / BMC
Box 815
751 08 Uppsala
- Akademiska meriter:
- MD PhD, Docent
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Kort presentation
Min forskning behandlar hur nervceller och omgivande sk gliaceller reagerar på perifer nervskada eller skada på ryggmärgens sensoriska rötter. Forskningen har bl.a. visat att molekyler tillhörande immunsystemet börjar bildas av sk mikrogliaceller efter dessa skador. Vi har också visat att förlorade sensoriska funktioner kan återges genom transplantation av omogna sensoriska nervceller. Aktuell forskning avser nya tillvägagångssätt för att behandla ryggmärgsskada med transplantat av stamceller.
Nyckelord
- glia cells
- neuronal regeneration
- spinal cord
- stem cells
- transplantation
Biografi
Professor i medicinsk strukturbiologi, Uppsala universitet, 1995-2010 (fn emeritus)
Prefekt, Instiltutionen för neurovetenskap, Uppsala universitet, 2006-2010
Universitetslektor i anatomi, Karolinska institutet, 1984-1995
Vik. universitetslektor i anatomi, Karolinska institutet, 1982-1984
Postdoktorstipendiat (US Public Health Service Fogarty Fellowship) i neurologi, Albany Medical College, NY
Docent i anatomi, Karolinska institutet, 1976-1982
Forskarassistent, Karolinska institutet, 1974-1976
Medicine doktor i anatomi, Karolinska institutet, 1974
Läkarlegitimation, 1971
Läkarexamen, Uppsala universitet, 1971
158 vetenskaplig publikation i PubMed
18 vetenskapliga bokkapitel
Läroböcker:
B. Norrving, H. Aldskogius mfl. Klinisk neurovetenskap. Liber 2015
H. Aldskogius & B. Rydqvist, Den friska människan. Liber 2018
H. Aldskogius & B. Rydqvist, Arbetsbok Den friska människan. Liber 2019
Publikationer
Urval av publikationer
- A Combinatorial Approach to Induce Sensory Axon Regeneration into the Dorsal Root Avulsed Spinal Cord (2017)
- Murine neural crest stem cells and embryonic stem cell derived neuron precursors survive and differentiate after transplantation in a model of dorsal root avulsion (2017)
- Segmentation of the inferior longitudinal fasciculus in the human brain (2017)
- Human Embryonic Stem Cell-Derived Progenitors Assist Functional Sensory Axon Regeneration after Dorsal Root Avulsion Injury (2015)
- The Classical Pathways of Occipital Lobe Epileptic Propagation Revised in the Light of White Matter Dissection (2015)
- The use of a cerebral perfusion and immersion-fixation process for subsequent white matter dissection (2015)
- Microglia and Neuropathic Pain (2013)
- Delivery of Differentiation Factors by Mesoporous Silica Particles Assists Advanced Differentiation of Transplanted Murine Embryonic Stem Cells (2013)
- Animal models of spinal cord repair (2012)
- Mechanisms and consequences of microglial responses to peripheral axotomy (2011)
- Regulation of boundary cap neural crest stem cell differentiation after transplantation (2009)
- Long-term survival, robust neuronal differentiation, and extensive migration of human forebrain stem/progenitor cells transplanted to the adult rat dorsal root ganglion cavity (2008)
Senaste publikationer
- Dorsal Root Injury (2021)
- A Combinatorial Approach to Induce Sensory Axon Regeneration into the Dorsal Root Avulsed Spinal Cord (2017)
- Murine neural crest stem cells and embryonic stem cell derived neuron precursors survive and differentiate after transplantation in a model of dorsal root avulsion (2017)
- Segmentation of the inferior longitudinal fasciculus in the human brain (2017)
- Human Embryonic Stem Cell-Derived Progenitors Assist Functional Sensory Axon Regeneration after Dorsal Root Avulsion Injury (2015)
Alla publikationer
Artiklar
- Dorsal Root Injury (2021)
- A Combinatorial Approach to Induce Sensory Axon Regeneration into the Dorsal Root Avulsed Spinal Cord (2017)
- Murine neural crest stem cells and embryonic stem cell derived neuron precursors survive and differentiate after transplantation in a model of dorsal root avulsion (2017)
- Segmentation of the inferior longitudinal fasciculus in the human brain (2017)
- Human Embryonic Stem Cell-Derived Progenitors Assist Functional Sensory Axon Regeneration after Dorsal Root Avulsion Injury (2015)
- The Classical Pathways of Occipital Lobe Epileptic Propagation Revised in the Light of White Matter Dissection (2015)
- The use of a cerebral perfusion and immersion-fixation process for subsequent white matter dissection (2015)
- Microglia and Neuropathic Pain (2013)
- Delivery of Differentiation Factors by Mesoporous Silica Particles Assists Advanced Differentiation of Transplanted Murine Embryonic Stem Cells (2013)
- Mechanisms and consequences of microglial responses to peripheral axotomy (2011)
- Forced Runx1 expression in human neural stem/progenitor cells transplanted to the rat dorsal root ganglion cavity results in extensive axonal growth specifically from spinal cord-derived neurospheres (2011)
- Regulation of boundary cap neural crest stem cell differentiation after transplantation (2009)
- The impact of neurotrophin-3 on the dorsal root transitional zone following injury (2008)
- Megalin deficiency induces critical changes in early glial development in mouse spinal cord (2008)
- Extracellular clusterin promotes neuronal network complexity in vitro (2008)
- Long-term survival, robust neuronal differentiation, and extensive migration of human forebrain stem/progenitor cells transplanted to the adult rat dorsal root ganglion cavity (2008)
- Spinal cord injury (2007)
- Central nervous system stem/progenitor cells form neurons and peripheral glia after transplantation to the dorsal root ganglion. (2006)
- Low density lipoprotein-related protein-2/megalin is expressed in oligodendrocytes in the mouse spinal cord white matter (2006)
- Repairing CNS myelin (2005)
- Adult motor neurons show increased susceptibility to axotomy-induced death in mice lacking clusterin (2005)
- Low-density lipoprotein receptor-related protein (LRP)-2/megalin is transiently expressed in a subpopulation of neural progenitors in the embryonic mouse spinal cord (2005)
- Suppressive silver methods - a tool for identifying axotomy-induced neuron degeneration (2004)
- Strategies for repair of the deafferented spinal cord (2002)
- Regulation of microglia (2001)
- Microglia in neuroregeneration (2001)
- Microglial activation, emergence of ED1-expressing cells and clusterin upregulation in the aging rat CNS, with special reference to the spinal cord (2001)
- Nimodipine promotes regeneration and functional recovery after intracranial facial nerve crush (2001)
- Functional connections are established in the deafferented rat spinal cord by peripherally transplanted human embryonic sensory neurons (2000)
- Hereditary absence of complement C5 in adult mice influences Wallerian degeneration, but not retrograde responses, following injury to peripheral nerve (1999)
- Clusterin upregulation following rubrospinal tract lesion in the adult rat (1999)
- Nimodipine-induced improved survival rate of facial motor neurons following intracranial transection of the facial nerve in the adult rat (1999)
- The novel pyrrolopyrimidine PNU-101033-E improves facial motor neuron survival following intracranial axotomy of the facial nerve in the adult rat (1999)
- Glial cell responses, complement and apolipoprotein J expression following axon injury in the neonatal rat (1999)
- Central neuron-glial and glial-glial interactions following axon injury (1998)
- Ultrastructural localization of immunoglobulin G and complement C9 in the brain stem and spinal cord following peripheral nerve injury (1998)
- Glial Cell Responses, Complement and Clusterin in the Central Nervous System Following Dorsal Root Transection (1998)
- Differential dependency of unmyelinated and A delta epidermal and upper dermal innervation on neurotrophins, trk receptors, and p75LNGFR (1998)
- Influence of FK506, cyclosporin A, testosterone and nimodipine on motoneuron survival following axotomy (1998)
- Differential dependency of developing mechanoreceptors on neurotrophins, trk receptors, and p75LNGFR (1997)
- A comprehensive immunofluorescence and lectin binding analysis of intervibrissal fur innervation in the mystacial pad of the rat (1997)
- Human dorsal root ganglion neurons from embryonic donors extend axons into the host rat spinal cord along laminin-rich peripheral surroundings of the dorsal root transitional zone (1997)
- A comprehensive immunofluorescence and lectin binding analysis of vibrissal follicle sinus complex innervation in the mystacial pad of the rat (1997)
Böcker
