Luke Odell
Professor vid Institutionen för läkemedelskemi; Preparativ läkemedelskemi
- Telefon:
- 018-471 42 97
- Fax:
- 018-471 44 74
- E-post:
- luke.odell@ilk.uu.se
- Besöksadress:
- Uppsala Biomedicinska Centrum, BMC, Husarg. 3
- Postadress:
- Box 574
751 23 UPPSALA
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Biografi
Denna text finns inte på svenska, därför visas den engelska versionen.
Luke Odell was born in Tamworth, Australia in 1981. He graduated with an Honours BSc. in Forensic Science from the University of Newcastle, Australia in 2002. He completed his PhD studies at the same university under the guidance of Professor Adam McCluskey in 2006 working on the synthesis of enzyme inhibitors. In 2006, he took up a postdoctoral position with Professor Mats Larhed at Uppsala University. In 2016 he was appointed as a Senior Lecturer and was promoted to Full Professor in 2022. His research interests include molecular imaging, heterocyclic chemistry, PET chemistry and medicinal chemistry.
Publikationer
Urval av publikationer
- The Wittig Bioconjugation of Maleimide Derived, Water Soluble Phosphonium Ylides to Aldehyde-Tagged Proteins (2021)
- Spatial visualization of comprehensive brain neurotransmitter systems and neuroactive substances by selective in situ chemical derivatization mass spectrometry imaging (2021)
- Sustainability in drug discovery (2021)
- Rational Design of Azastatin as a Potential ADC Payload with Reduced Bystander Killing. (2020)
- Synthesis and preclinical evaluation of the CRTH2 antagonist [11C]MK-7246 as a novel PET tracer and potential surrogate marker for pancreatic beta-cell mass (2019)
- Palladium(0)-Catalyzed Carbonylative Synthesis of N-Acylsulfonamides via Regioselective Acylation (2019)
- Comprehensive mapping of neurotransmitter networks by MALDI-MS imaging (2019)
- Thiomethylation, Nitro Reduction and Tandem Reduction/SMe Insertion of Nitrogen Heterocycles Using BF3⦁SMe2 (2019)
- Synthesis of N-Sulfonyl Amidines and Acyl Sulfonyl Ureas from Sulfonyl Azides, Carbon Monoxide, and Amides (2017)
- Palladium-mediated C-11-carbonylations using aryl halides and cyanamide (2017)
- Palladium and Visible-Light Mediated Carbonylative Suzuki-Miyaura Coupling of Unactivated Alkyl Halides and Aryl Boronic Acids (2017)
- Acetic acid-promoted cascade N-acyliminium ion/aza-Prins cyclization (2017)
- Sulfonyl Azides as Precursors in Ligand-free Palladium-Catalyzed Synthesis of Sulfonyl Carbamates and Sulfonyl Ureas and Synthesis of Sulfonamides (2016)
- Microwave-Assisted Branching Cascades (2016)
Senaste publikationer
- Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for PET (2024)
- [18F]MK-7246 for Positron Emission Tomography Imaging of the Beta-Cell Surface Marker GPR44 (2023)
- On-Tissue Chemical Derivatization for Comprehensive Mapping of Brain Carboxyl and Aldehyde Metabolites by MALDI-MS Imaging (2023)
- Synthesis of Substituted Indazole Acetic Acids by N-N Bond Forming Reactions (2023)
- Acyl Amidines by Pd-Catalyzed Aminocarbonylation (2023)
Alla publikationer
Artiklar
- Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for PET (2024)
- [18F]MK-7246 for Positron Emission Tomography Imaging of the Beta-Cell Surface Marker GPR44 (2023)
- On-Tissue Chemical Derivatization for Comprehensive Mapping of Brain Carboxyl and Aldehyde Metabolites by MALDI-MS Imaging (2023)
- Synthesis of Substituted Indazole Acetic Acids by N-N Bond Forming Reactions (2023)
- Acyl Amidines by Pd-Catalyzed Aminocarbonylation (2023)
- A Base-Free, Low Temperature Click and Release Reaction for the In Situ Generation of Diazomethane (2023)
- Thioacetalation and Multi-Component Thiomethylative Friedel-Crafts Arylation Using BF3SMe2 (2023)
- Region-Specific and Age-Dependent Multitarget Effects of Acetylcholinesterase Inhibitor Tacrine on Comprehensive Neurotransmitter Systems (2022)
- Pyrimidyn‐Based Dynamin Inhibitors as Novel Cytotoxic Agents (2022)
- Prodrugs of the Archetypal Dynamin Inhibitor Bis-T-22 (2022)
- P-119 - Efficient cartridge-based synthesis of a novel [18F]tetrazine for large molecule labelling (2022)
- Synthesis of substituted 3,4-dihydroquinazolinones via a metal free Leuckart-Wallach type reaction (2021)
- PET Imaging of GPR44 by Antagonist [C-11]MK-7246 in Pigs (2021)
- Mass spectrometry imaging identifies abnormally elevated brain L-DOPA levels and extrastriatal monoaminergic dysregulation in L-DOPA-induced dyskinesia (2021)
- The Wittig Bioconjugation of Maleimide Derived, Water Soluble Phosphonium Ylides to Aldehyde-Tagged Proteins (2021)
- Spatial visualization of comprehensive brain neurotransmitter systems and neuroactive substances by selective in situ chemical derivatization mass spectrometry imaging (2021)
- Sustainability in drug discovery (2021)
- Regio- and Stereoselective Synthesis of Allylic Spiroethers (Spirobenzofuranes) via an Intramolecular Mizoroki-Heck Reaction (2020)
- Rational Design of Azastatin as a Potential ADC Payload with Reduced Bystander Killing. (2020)
- Turning Information Dissipation into Dissemination (2020)
- Synthesis and preclinical evaluation of the CRTH2 antagonist [11C]MK-7246 as a novel PET tracer and potential surrogate marker for pancreatic beta-cell mass (2019)
- Palladium(0)-Catalyzed Carbonylative Synthesis of N-Acylsulfonamides via Regioselective Acylation (2019)
- Comprehensive mapping of neurotransmitter networks by MALDI-MS imaging (2019)
- Thiomethylation, Nitro Reduction and Tandem Reduction/SMe Insertion of Nitrogen Heterocycles Using BF3⦁SMe2 (2019)
- Palladium-Catalyzed Molybdenum Hexacarbonyl-Mediated Gas-Free Carbonylative Reactions (2019)
- Carbonylations beyond aryl-X (2018)
- Microwave-Assisted aza-Friedel-Crafts Arylation of N-Acyliminium Ions (2018)
- Synthesis of 11C-Labelled Ureas by Palladium(II)-Mediated Oxidative Carbonylation (2017)
- Synthesis of N-Sulfonyl Amidines and Acyl Sulfonyl Ureas from Sulfonyl Azides, Carbon Monoxide, and Amides (2017)
- Low-Pressure Radical 11C-Aminocarbonylation of Alkyl Iodides through Thermal Initiation (2017)
- Palladium-mediated C-11-carbonylations using aryl halides and cyanamide (2017)
- Pyrimidine-Based Inhibitors of Dynamin I GTPase Activity (2017)
- Synthesis and In Vitro Evaluation of 5-Substituted Benzovesamicol Analogs containing N-Substituted Amides as Potential Positron Emission Tomography Tracers for the Vesicular Acetylcholine Transporter (2017)
- Visible-Light Photocatalysis as an Enabling Tool for the Functionalization of Unactivated C(sp(3))-Substrates (2017)
- Palladium and Visible-Light Mediated Carbonylative Suzuki-Miyaura Coupling of Unactivated Alkyl Halides and Aryl Boronic Acids (2017)
- Route to 3-Amidino Indoles via Pd(II)-Catalyzed C-H Bond Activation (2017)
- Acetic acid-promoted cascade N-acyliminium ion/aza-Prins cyclization (2017)
- Synthesis of 4H-Benzo[e][1,3]oxazin-4-ones by a Carbonylation-Cyclization Domino Reaction of ortho-Halophenols and Cyanamide (2017)
- Palladium(0)-Catalyzed Carbonylative One-Pot Synthesis of N-Acylguanidines (2017)
- Sulfonyl Azides as Precursors in Ligand-free Palladium-Catalyzed Synthesis of Sulfonyl Carbamates and Sulfonyl Ureas and Synthesis of Sulfonamides (2016)
- Low-Pressure Radical C-11-Aminocarbonylation of Alkyl Iodides through Thermal Initiation (2016)
- Mild and Low-Pressure fac-Ir(ppy)3-Mediated Radical Aminocarbonylation of Unactivated Alkyl Iodides through Visible-Light Photoredox Catalysis (2016)
- Microwave-Assisted Branching Cascades (2016)
- Synthesis of sodium aryl sulfinates from aryl bromides employing 1,4-diazabicyclo[2.2.2]octane bis(sulfur dioxide) adduct (DABSO) as a bench-stable, gas-free alternative to SO2 (2016)
- Synthesis of 11C-labelled Sulfonyl Carbamates via a Multicomponent Reaction Employing Sulfonyl Azides, Alcohols and [11C]CO (2016)
- Synthesis of C-11-labeled Sulfonyl Carbamates through a Multicomponent Reaction Employing Sulfonyl Azides, Alcohols, and [C-11]CO (2016)
- Synthesis of 2-Aminoquinazolinones via Carbonylative Coupling of ortho-lodoanilines and Cyanamide (2016)
- Mild and Low-Pressure fac-Ir(ppy)3-Mediated Radical Aminocarbonylation of Unactivated Alkyl Iodides through Visible-Light Photoredox Catalysis (2016)
- 1,8-Naphthalimide derivatives (2015)
- Rapid Access to Polyfunctionalized 3,4-Dihydroquinazolinones through a Sequential N-Acyliminium Ion Mannich Reaction Cascade (2015)
- 3,4-Dihydro-3-(2-hydroxyethyl)-4-(nitromethyl)quinazolin-2(1H)-one (2015)
- A microwave-assisted multicomponent synthesis of substituted 3,4-dihydroquinazolinones (2015)
- Cyclic amidines as precursors for imidazoles (2015)
- Synthesis of 4-Quinolones via a Carbonylative Sonogashira Cross-Coupling Using Molybdenum Hexacarbonyl as a CO Source (2015)
- An Improved Palladium(II)-Catalyzed Method for the Synthesis of Aryl Ketones from Aryl Carboxylic Acids and Organonitriles (2014)
- Syntheses of new tuberculosis inhibitors promoted by microwave irradiation (2014)
- Development of quinone analogues as dynamin GTPase inhibitors (2014)
- Aspartic protease inhibitors containing tertiary alcohol transition-state mimics (2014)
- Inhibition of Glutamine Synthetase (2014)
- C-11-Labeling of a potent hydroxyethylamine BACE-1 inhibitor and evaluation in vitro and in vivo (2014)
- 11C-Labeling of a Potent Hydroxyethylamine BACE-1 Inhibitor and Evaluation in vitro and in vivo (2014)
- Synthesis of sulfonyl azides via diazotransfer using an imidazole-1-sulfonyl azide salt: scope and ¹⁵N NMR labeling experiments (2014)
- Synthesis of arylsulfonyl azides via diazotransfer using an imidazole-1-sulfonyl azide salt (2014)
- Synthesis and evaluation of isoleucine derived angiotensin II AT(2) receptor ligands (2014)
- Palladium-Catalyzed Carbonylative Synthesis of N-Cyanobenzamides from Aryl Iodides/Bromides and Cyanamide (2013)
- Pyrimidyn Compounds (2013)
- A Novel p53 Mutant Found in Iatrogenic Urothelial Cancers Is Dysfunctional and Can Be Rescued by a Second-site Global Suppressor Mutation (2013)
- Decarboxylative Palladium(II)-Catalyzed Synthesis of Aryl Amidines from Aryl Carboxylic Acids (2013)
- Organocatalytic asymmetric cross-aldol reaction of 2-chloroethoxy acetaldehyde (2013)
- Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors (2012)
- Microwave-assisted synthesis of small molecules targeting the infectious diseases tuberculosis, HIV/AIDS, malaria and hepatitis C (2012)
- Aminocarbonylations Employing Mo(CO)(6) and a Bridged Two-Vial System (2012)
- Synthesis, biological evaluation and X-ray crystallographic studies of imidazo[1,2-a]-pyridine based Mycobacterium tuberculosis glutamine synthetase inhibitors (2012)
- Molybdenum Hexacarbonyl Mediated CO Gas-Free Carbonylative Reactions (2012)
- Transmetallation Versus β-Hydride Elimination (2012)
- Direct Palladium(II)-Catalyzed Synthesis of Arylamidines from Aryltrifluoroborates (2012)
- Development of Stereocontrolled Palladium(II)-Catalyzed Domino Heck/Suzuki β, α-Diarylation Reactions with Chelating Vinyl Ethers and Arylboronic Acids (2012)
- A microwave-assisted, propylphosphonic anhydride (T3P (R)) mediated one-pot Fischer indole synthesis (2011)
- Richard F. Heck (2011)
- Microwave-Assisted Synthesis of Weinreb and MAP Aryl Amides via Pd-Catalyzed Heck Aminocarbonylation Using Mo(CO)(6) or W(CO)(6) (2011)
- Iminochromene Inhibitors of Dynamins I and II GTPase Activity and Endocytosis (2010)
- The Pthaladyns (2010)
- Continuous Flow Palladium(II) (2010)
- Inhibition of dynamin mediated endocytosis by the dynoles (2009)
- A versatile new synthetic route to 1N-hydroxyindazoles (2009)
- Azido and diazarinyl analogues of bis-tyrphostin as asymmetrical inhibitors of dynamin GTPase (2009)
- Functionalized 3-amino-imidazo[1,2-a]pyridines (2009)
- Evaluation of the amino acid binding site of Mycobacterium tuberculosis glutamine synthetase for drug discovery (2008)
- Isolation and identification of unique marker compounds from the Tasmanian poppy Papaver somniferum N. Implications for the identification of illicit heroin of Tasmanian origin. (2008)
- Microwave-promoted aminocarbonylation of aryl triflates using Mo(CO)(6) as a solid CO source (2008)
- Microwave-enhanced alpha-arylation of a protected glycine in water (2007)
- Crystal and Molecular Structures of Benzyl-(2-chloro-6-methylpyrimidin-4-yl)amine and Benzyl-(4-chloro-6-methylpyrimidin-2-yl)amine (2007)
- A 'cold synthesis' of heroin and implications in heroin signature analysis utility of trifluoroacetic/acetic anhydride in the acetylation of morphine. (2006)
- Small molecule inhibitors of dynamin I GTPase activity (2005)
- BiCl3-mediated opening of epoxides, a facile route to chlorohydrins or amino alcohols (2005)
- Identification of Aminopyrimidine Regioisomers via Line Broadening Effects in 1H and 13C NMR Spectroscopy (2004)
- Long chain amines and long chain ammonium salts as novel inhibitors of dynamin GTPase activity. (2004)
- Late-Stage Defluorinative Functionalization: Synthesis of Methyl-Dithioesters and Thioamides from Trifluoromethylarenes
Kapitel
- Microwave-assisted synthesis of anti-tuberculosis, HIV and hepatitis C agents (2014)
- 7.18 Addition Reactions with Formation of Carbon–Carbon Bonds (2014)
- Alkenes with Metal-Directing Groups as Reaction Components (2013)
- Microwave-Heated Transition Metal-Catalyzed Coupling Reactions (2012)
- Microwave-Assisted Transition Metal-Catalyzed Asymmetric Synthesis (2011)
- Microwave-accelerated homogenous catalysis in water (2009)
