Örjan Carlborg
Professor vid Institutionen för medicinsk biokemi och mikrobiologi; Genetik och genomik; Örjan Carlborg
- Telefon:
- 018-471 45 92
- Mobiltelefon:
- 070-167 97 64
- E-post:
- orjan.carlborg@imbim.uu.se
- Besöksadress:
- BMC
Husargatan 3
752 37 UPPSALA - Postadress:
- Box 582
751 23 UPPSALA
- ORCID:
- 0000-0002-2722-5264
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Kort presentation
Jag letar efter gener i arvsmassan som gör att individer inom en art skiljer sig åt. Detta gör jag genom att utveckla nya genetiska modeller och statistiska analysmetoder att kartlägga hur olika varianter av gener påverkar deras bidrag till olika egenskaper. Arbetet gör att vi på ett bättre sätt utnyttjar de enorma mängder genetiska data som samlas in idag och att vi i framtiden kommer kunna utnyttja genetisk information på bättre sätt inom medicinen.
Nyckelord
- bioinformatik
- genetik
- genomik
- komplexa sjukdomar
- statistik
Publikationer
Senaste publikationer
- Whole-genome selective sweep analyses identifies the region and candidate gene associated with white earlobe color in Mediterranean chickens (2024)
- Mapping and Functional Dissection of the Rumpless Trait in Piao Chicken Identifies a Causal Loss of Function Mutation in the Novel Gene Rum (2023)
- Low-coverage sequencing in a deep intercross of the Virginia body weight lines provides insight to the polygenic genetic architecture of growth (2023)
- Researching on the fine structure and admixture of the worldwide chicken population reveal connections between populations and important events in breeding history (2021)
- Multiple ancestral haplotypes harboring regulatory mutations cumulatively contribute to a QTL affecting chicken growth traits (2020)
Alla publikationer
Artiklar
- Whole-genome selective sweep analyses identifies the region and candidate gene associated with white earlobe color in Mediterranean chickens (2024)
- Mapping and Functional Dissection of the Rumpless Trait in Piao Chicken Identifies a Causal Loss of Function Mutation in the Novel Gene Rum (2023)
- Low-coverage sequencing in a deep intercross of the Virginia body weight lines provides insight to the polygenic genetic architecture of growth (2023)
- Researching on the fine structure and admixture of the worldwide chicken population reveal connections between populations and important events in breeding history (2021)
- Multiple ancestral haplotypes harboring regulatory mutations cumulatively contribute to a QTL affecting chicken growth traits (2020)
- Haplotype Purging after Relaxation of Selection in Lines of Chickens That Had Undergone Long-Term Selection for High and Low Body Weight (2020)
- Dissecting the Genetic Regulation of Yeast Growth Plasticity in Response to Environmental Changes (2020)
- Dynamic genetic architecture of yeast response to environmental perturbation shed light on origin of cryptic genetic variation (2020)
- A genomic inference of the White Plymouth Rock genealogy (2019)
- Bidirectional Selection for Body Weight on Standing Genetic Variation in a Chicken Model (2019)
- A polygenic genetic architecture of flowering time in the worldwide Arabidopsis thaliana population. (2019)
- Genotyping by low-coverage whole-genome sequencing in intercross pedigrees from outbred founders (2019)
- Genomic signatures of 60 years of bidirectional selection for 8-week body weight in chickens (2018)
- A multi-locus association analysis method integrating phenotype and expression data reveals multiple novel associations to flowering time variation in wild-collected Arabidopsis thaliana. (2018)
- On the Relationship Between High-Order Linkage Disequilibrium and Epistasis (2018)
- Imputation-Based Fine-Mapping Suggests That Most QTL in an Outbred Chicken Advanced Intercross Body Weight Line Are Due to Multiple, Linked Loci (2017)
- Accounting for genetic interactions improves modeling of individual quantitative trait phenotypes in yeast (2017)
- On the relationship between epistasis and genetic variance heterogeneity. (2017)
- Genome-wide standing variation facilitates long-term response to bidirectional selection for antibody response in chickens (2017)
- Genetics of Interactive Behavior in Silver Foxes (Vulpes vulpes) (2017)
- Artificial Selection Response due to Polygenic Adaptation from a Multilocus, Multiallelic Genetic Architecture. (2017)
- A Complex Structural Variation on Chromosome 27 Leads to the Ectopic Expression of HOXB8 and the Muffs and Beard Phenotype in Chickens (2016)
- Genetic Regulation of Transcriptional Variation in Natural Arabidopsis thaliana Accessions (2016)
- Mitogenomic analysis of a 50-generation chicken pedigree reveals a rapid rate of mitochondrial evolution and evidence for paternal mtDNA inheritance (2015)
- Reassess the t Test (2015)
- The Multi-allelic Genetic Architecture of a Variance-Heterogeneity Locus for Molybdenum Concentration in Leaves Acts as a Source of Unexplained Additive Genetic Variance. (2015)
- The Shepherds' Tale (2015)
- cgmisc (2015)
- A Genome-Wide Association Analysis Reveals Epistatic Cancellation of Additive Genetic Variance for Root Length in Arabidopsis thaliana. (2015)
- Capacitating epistasis--detection and role in the genetic architecture of complex traits. (2015)
- Standing genetic variation as a major contributor to adaptation in the Virginia chicken lines selection experiment. (2015)
- Multiple Changes of Gene Expression and Function Reveal Genomic and Phenotypic Complexity in SLE-like Disease (2015)
- Genetic influences on brain gene expression in rats selected for tameness and aggression. (2014)
- Natural CMT2 variation is associated with genome-wide methylation changes and temperature seasonality. (2014)
- Identification of candidate genes and mutations in QTL regions for chicken growth using bioinformatic analysis of NGS and SNP-chip data. (2013)
- Identification of Null Alleles and Deletions from SNP Genotypes for an Intercross Between Domestic and Wild Chickens (2013)
- PASE (2013)
- Higher order interactions (2013)
- MAPfastR (2013)
- A century after Fisher (2013)
- Variance heterogeneity in Saccharomyces cerevisiae expression data (2013)
- Dynamics of adaptive alleles in divergently selected body weight lines of chickens. (2013)
- Beware of risk for increased false positive rates in genome-wide association studies for phenotypic variability. (2013)
- Genetic dissection of growth traits in a Chinese indigenous × commercial broiler chicken cross. (2013)
- Genome-Wide Analysis in German Shepherd Dogs Reveals Association of a Locus on CFA 27 with Atopic Dermatitis (2013)
- Estimation and interpretation of genetic effects with epistasis using the NOIA model. (2012)
- Modelling of genetic interactions improves prediction of hybrid patterns (2012)
- Generation of a multi-locus chicken introgression line to study the effects of genetic interactions on metabolic phenotypes in chickens. (2012)
- Mapping QTL affecting a systemic sclerosis-like disorder in a cross between UCD-200 and red jungle fowl chickens (2012)
- A genome-wide association study using international breeding-evaluation data identifies major loci affecting production traits and stature in the Brown Swiss cattle breed. (2012)
- Coherent estimates of genetic effects with missing information (2012)
- Selection on variance-controlling genes (2012)
- Strong signatures of selection in the domestic pig genome (2012)
- Inheritance beyond plain heritability (2012)
- Targeted resequencing of a genomic region influencing tameness and aggression reveals multiple signals of positive selection (2011)
- Fine mapping and replication of QTL in outbred chicken advanced intercross lines (2011)
- An improved method for estimating chromosomal line origin in QTL analysis of crosses between outbred lines (2011)
- qtl.outbred (2011)
- qtl.outbred: interfacing outbred line cross data with the R/qtl mapping software (2011)
- Replication and Explorations of High-Order Epistasis Using a Large Advanced Intercross Line Pedigree (2011)
- How to deal with genotype uncertainty in variance component quantitative trait loci analyses (2011)
- Hierarchical likelihood opens a new way of estimating genetic values using genome-wide dense marker maps. (2011)
- Hierarchical likelihood opens a new way of estimating genetic values using genome-wide dense marker maps (2011)
- Genetic analysis of metabolic traits in an intercross between body weight-selected chicken lines (2010)
- Genome-Wide Effects of Long-Term Divergent Selection (2010)
- Genomic Analysis of Variation in Hindlimb Musculature of Mice from the C57BL/6J and DBA/2J Lineage (2010)
- SNP detection and prediction of variability between chicken lines using genome resequencing of DNA pools (2010)
- Whole genome resequencing reveals loci under selection during chicken domestication (2010)
- Genetic architecture of tameness in a rat model of animal domestication (2009)
- A genetic algorithm based method for stringent haplotyping of family data (2009)
- Comparison of analyses of the QTLMAS XII common dataset. II (2009)
- Comparison of analyses of the QTLMAS XII common dataset. I (2009)
- Modelling dominance in a flexible intercross analysis. (2009)
- Genetic analysis of an F2 intercross between two chicken lines divergently selected for body-weight (2009)
- How to perform meaningful estimates of genetic effects (2008)
- Dissection of the genetic architecture of body weight in chicken reveals the impact of epistasis on domestication traits (2008)
- Evolutionary potential of hidden genetic variation (2008)
- An Improved Method for Quantitative Trait Loci Detection and Identification of Within-Line Segregation in F2 Intercross Designs (2008)
- Defining the assumptions underlying modeling of epistatic QTL using variance component methods (2008)
- A general and efficient method for estimating continuous IBD functions for use in genome scans for QTL (2007)
- Statistical epistasis is a generic feature of gene regulatory networks (2007)
- Phenotypic evolution from genetic polymorphisms in a radial network architecture (2007)
- Separation of base allele and sampling term effects gives new insights in variance component QTL analysis (2007)
- Increasing the efficiency of variance component quantitative trait loci analysis by using reduced-rank identity-by-descent matrices (2007)
- A unified model for functional and statistical epistasis and its application in quantitative trait loci analysis (2007)
- Epistasis and the release of genetic variation during long-term selection. (2006)
- Epistatic regulation of behavioural and morphological traits in the zebrafish (Danio rerio) (2006)
- Simultaneous mapping of epistatic QTL in DU6i x DBA/2 mice. (2005)
- Methodological aspects of the genetic dissection of gene expression. (2005)
- The genetic dissection of immune response using gene-expression studies and genome mapping. (2005)
- Epistasis (2004)
- Simultaneous mapping of epistatic QTL in chickens reveals clusters of QTL pairs with similar genetic effects on growth. (2004)
- Chicken genomics: Feather-pecking and victim pigmentation (2004)
- Chicken genomics (2004)
- Simultaneous search for multiple QTL using the global optimization algorithm DIRECT (2004)
- Major Growth QTLs in Fowl Are Related to Fearful Behavior (2004)
- Major growth QTLs in fowl are related to fearful behavior (2004)
- A global search reveals epistatic interaction between QTL for early growthin the chicken (2003)
- A global search reveals epistatic interaction between QTL for early growth in the chicken. (2003)
- A Global Search Reveals Epistatic Interaction Between QTL for Early Growth in the Chicken (2003)
- The twofold difference in adult size between the red junglefowl and WhiteLeghorn chickens is largely explained by a limited number of QTLs (2003)
- The twofold difference in adult size between the red junglefowl and White Leghorn chickens is largely explained by a limited number of QTLs. (2003)
- The twofold difference in adult size between the red junglefowl and White Leghorn chickens is largely explained by a limited number of QTLs (2003)
- Use of randomization testing to detect multiple epistatic QTLs. (2002)
- Parallel computing in interval mapping of quantitative trait loci. (2002)
- Efficient algorithms for quantitative trait loci mapping problems (2002)
- Melanocortin-4 receptor (MC4R) genotypes have no major effect on fatness in a Large White x Wild Boar intercross. (2002)
- Melanocortin-4 receptor(MC4R) genotypes have no major effect on fatness in a Large White x Wild boar intercross (2002)
- QTL analysis of a red junglefowl x White Leghorn intercross reveals trade-off in resource allocation between behavior and production traits (2002)
- The use of a genetic algorithm for simultaneous mapping of multiple interacting quantitative trait loci. (2000)
- The origin of the domestic pig (2000)
- A paternally expressed QTL affecting skeletal and cardiac muscle mass in pigs maps to the IGF2 locus. (1999)
- High in situ rat intestinal permeability of artemisinin unaffected by multiple dosing and with no evidence of P-glycoprotein involvement (1999)
- High in situ rat intestinal permeability of artemisinin unaffected bymultiple dosing and with no evidence of P-glycoprotein involvement (1999)
- Within-line segregation as contributors to long-term, single-trait selection-responses in the Virginia chicken lines
- Mapping and dissecting capacitating epistasis in a population subjected to long-term, directional selection
Konferenser
Rapporter
