Johan Gising
Forskare vid Institutionen för läkemedelskemi; Läkemedelsdesign och läkemedelsutveckling
- Telefon:
- 018-471 43 38
- E-post:
- johan.gising@ilk.uu.se
- Besöksadress:
- Biomedicinskt Centrum BMC, Husargatan 3
- Postadress:
- Box 574
751 23 UPPSALA
Forskare vid Institutionen för materialvetenskap; Nanoteknologi och funktionella material
- E-post:
- johan.gising@angstrom.uu.se
- Besöksadress:
- Ångströmlaboratoriet, Lägerhyddsvägen 1
- Postadress:
- Box 35
751 03 UPPSALA
- ORCID:
- 0000-0001-8852-6071
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Kort presentation
Publikationer
Urval av publikationer
- Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB) (2017)
- Discovery of pyrazinone based compounds that potently inhibit the drug resistant enzyme variant R155K of the hepatitis C virus NS3 protease (2016)
- Efficient and Selective Palladium-Catalysed C-3 Urea Couplings to 3,5-Dichloro-2(1H)-pyrazinones (2015)
- Optimization and Evaluation of 5-Styryl-Oxathiazol-2-one Mycobacterium tuberculosis Proteasome Inhibitors as Potential Antitubercular Agents (2015)
- Syntheses of new tuberculosis inhibitors promoted by microwave irradiation (2014)
- Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket (2014)
- Microwave-assisted synthesis of anti-tuberculosis, HIV and hepatitis C agents (2014)
- Design and Synthesis of Enzyme Inhibitors Against Infectious Diseases (2012)
- Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors (2012)
- Microwave-assisted synthesis of small molecules targeting the infectious diseases tuberculosis, HIV/AIDS, malaria and hepatitis C (2012)
- Synthesis, biological evaluation and X-ray crystallographic studies of imidazo[1,2-a]-pyridine based Mycobacterium tuberculosis glutamine synthetase inhibitors (2012)
- Direct Palladium(II)-Catalyzed Synthesis of Arylamidines from Aryltrifluoroborates (2012)
- Structural Features Determining the Intestinal Epithelial Permeability and Efflux of Novel HIV-1 Protease Inhibitors (2011)
- Discovery of Achiral Inhibitors of the Hepatitis C Virus NS3 Protease based on 2(1H)-pyrazinones (2010)
- A straightforward microwave method for rapid synthesis of N-1, C-6 functionalized 3,5-dichloro-2(1H)-pyrazinones (2009)
- Functionalized 3-amino-imidazo[1,2-a]pyridines (2009)
- Variations of the P2 Group in HIV-1 Protease Inhibitors Containing a Tertiary Alcohol in the Transition-State Mimicking Scaffold (2006)
Senaste publikationer
- Inhibition of Insulin-Regulated Aminopeptidase by Imidazo[1,5-α]pyridines; Synthesis and Evaluation (2024)
- Toward biomass-based organic electronics: (2024)
- The Discovery of New Inhibitors of Insulin-Regulated Aminopeptidase by a High-Throughput Screening of 400,000 Drug-like Compounds (2024)
- The decanoate esters of nandrolone, testosterone, and trenbolone induce steroid specific memory impairment and somatic effects in the male rat (2024)
- Toward biomass-based organic electronics: Continuous flow synthesis and electropolymerization of N-substituted polypyrroles (2023)
Alla publikationer
Artiklar
- Inhibition of Insulin-Regulated Aminopeptidase by Imidazo[1,5-α]pyridines; Synthesis and Evaluation (2024)
- The Discovery of New Inhibitors of Insulin-Regulated Aminopeptidase by a High-Throughput Screening of 400,000 Drug-like Compounds (2024)
- The decanoate esters of nandrolone, testosterone, and trenbolone induce steroid specific memory impairment and somatic effects in the male rat (2024)
- Two-chamber Aminocarbonylation of Aryl Bromides and Triflates Using Amino Acids as Nucleophiles (2023)
- Diastereoselective Synthesis of N-Methylspiroindolines by Intramolecular Mizoroki–Heck Annulations (2022)
- 2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands (2022)
- Hydrogen Peroxide Induced Toxicity Is Reversed by the Macrocyclic IRAP-Inhibitor HA08 in Primary Hippocampal Cell Cultures (2022)
- ENABLE (2021)
- N-(Methyloxycarbonyl)thiophene sulfonamides as high affinity AT2 receptor ligands (2021)
- A Series of Analogues to the AT2R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode (2019)
- Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB) (2017)
- Discovery of pyrazinone based compounds that potently inhibit the drug resistant enzyme variant R155K of the hepatitis C virus NS3 protease (2016)
- Efficient and Selective Palladium-Catalysed C-3 Urea Couplings to 3,5-Dichloro-2(1H)-pyrazinones (2015)
- Optimization and Evaluation of 5-Styryl-Oxathiazol-2-one Mycobacterium tuberculosis Proteasome Inhibitors as Potential Antitubercular Agents (2015)
- Syntheses of new tuberculosis inhibitors promoted by microwave irradiation (2014)
- Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket (2014)
- Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors (2012)
- Microwave-assisted synthesis of small molecules targeting the infectious diseases tuberculosis, HIV/AIDS, malaria and hepatitis C (2012)
- Synthesis, biological evaluation and X-ray crystallographic studies of imidazo[1,2-a]-pyridine based Mycobacterium tuberculosis glutamine synthetase inhibitors (2012)
- Direct Palladium(II)-Catalyzed Synthesis of Arylamidines from Aryltrifluoroborates (2012)
- Structural Features Determining the Intestinal Epithelial Permeability and Efflux of Novel HIV-1 Protease Inhibitors (2011)
- Hepatitis C protease inhibitors based on 2(1H)-pyrazinones (2010)
- Discovery of Achiral Inhibitors of the Hepatitis C Virus NS3 Protease based on 2(1H)-pyrazinones (2010)
- A straightforward microwave method for rapid synthesis of N-1, C-6 functionalized 3,5-dichloro-2(1H)-pyrazinones (2009)
- Functionalized 3-amino-imidazo[1,2-a]pyridines (2009)
- Variations of the P2 Group in HIV-1 Protease Inhibitors Containing a Tertiary Alcohol in the Transition-State Mimicking Scaffold (2006)
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