Alina Meyer
Doktorand vid Institutionen för farmaci; Läkemedelsformulering
- E-post:
- alina.meyer@farmaci.uu.se
- Besöksadress:
- Biomedicinskt Centrum BMC, Husargatan 3
752 37 Uppsala - Postadress:
- Box 580
751 23 UPPSALA
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Nyckelord
- adme
- adpkd
- drug discovery
- drug repurposing
- drugtrain
- kidney disease
- organoids
- pkpd
Forskning
Denna text finns inte på svenska, därför visas den engelska versionen.
The general aim of my PhD thesis is to pharmaceutically profile new repurposing candidates for the treatment of the hereditary kidney disease ADPKD. I will perform a series of ADME assays. Then, the intracellular compound concentration and the corresponding pharmacological effect will be investigated using 3D cultured kidney organoids and global proteomics. Furthermore, subcellular target and off-target interaction for lead candidates will be studied and the findings will be combined in a PBPK model.
The project is part of the EU 'DRUGtrain' network.
