Johan Wannberg
Forskare vid Institutionen för läkemedelskemi; Preparativ läkemedelskemi
- Telefon:
- 018-471 41 24
- Fax:
- 018-471 44 74
- E-post:
- Johan.Wannberg@scilifelab.uu.se
- Besöksadress:
- Uppsala Biomedicinska Centrum, BMC, Husarg. 3
- Postadress:
- Box 574
751 23 UPPSALA
- Akademiska meriter:
- apot. , Farm Dr.
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Kort presentation
Forskare vid faciliteten Medicinal Chemistry, Lead Identification, Drug Discovery and Development Platform, Science for Life Laboratory på Inst. f. Läkemedelskemi. Information om plattformen finns på https://www.scilifelab.se/platforms/ddd.
Leg. apotekare (1999) och FarmDr i Läkemedelskemi (2005). Åtta års erfarenhet från industri och mindre forskningsbolag.
Anställd på SciLifeLab DDD/ Inst. f. Läkemedelskemi från 2014. Utvecklar från 2018 DNA-kodade substansbibliotek vid plattformen.
Publikationer
Senaste publikationer
- Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress (2022)
- N-(Methyloxycarbonyl)thiophene sulfonamides as high affinity AT2 receptor ligands (2021)
- A Series of Analogues to the AT2R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode (2019)
- Biological characterization of new inhibitors of microsomal PGE synthase-1 in preclinical models of inflammation and vascular tone (2019)
- A convenient transesterification method for synthesis of AT2 receptor ligands with improved stability in human liver microsomes (2018)
Alla publikationer
Artiklar
- Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress (2022)
- N-(Methyloxycarbonyl)thiophene sulfonamides as high affinity AT2 receptor ligands (2021)
- A Series of Analogues to the AT2R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode (2019)
- Biological characterization of new inhibitors of microsomal PGE synthase-1 in preclinical models of inflammation and vascular tone (2019)
- A convenient transesterification method for synthesis of AT2 receptor ligands with improved stability in human liver microsomes (2018)
- Rapid and straightforward transesterification of sulfonyl carbamates (2016)
- Microwave Promoted Transcarbamylation Reaction of Sulfonylcarbamates under Continuous-Flow Conditions (2016)
- Synthesis of enantiopure angiotensin II type 2 receptor [AT(2)R] antagonist EMA401 (2015)
- Nonresonant microwave heated continuous flow synthesis in medicinal chemistry (2014)
- Microwave Heated Flow Synthesis of Spiro-oxindole Dihydroquinazolinone Based IRAP Inhibitors (2014)
- One-Pot, Two-Step, Microwave-Assisted Palladium-Catalyzed Conversion of Aryl Alcohols to Aryl Fluorides via Aryl Nonaflates (2013)
- HIV-1 Protease Inhibitors with a Transition-State Mimic Comprising a Tertiary Alcohol (2010)
- Controlled microwave heating as an enabling technology (2007)
- Stereoselective Synthesis of 3-Aminoindan-1-ones and Subsequent Incorporation into HIV-1 Protease Inhibitors (2006)
- Microwave-accelerated synthesis of protease inhibitors (2006)
- A New Structural Theme in C2-Symmetric HIV-1 Protease Inhibitors: ortho-Substituted P1/P1’ Side Chains (2006)
- Hydroxylamine as an ammonia equivalent in microwave-enhanced aminocarbonylations (2006)
- Microwave-Enhanced and Metal-Catalyzed Functionalizations of the 4-Aryl-Dihydropyrimidone Template (2005)
- High-Speed Synthesis of Potent C2-Symmetric HIV-1 Protease Inhibitors by in Situ Aminocarbonylations (2005)
- Microwave-enhanced medicinal chemistry (2004)
- Direct microwave synthesis of N,N'-diacylhydrazines and Boc-protected hydrazides by in situ carbonylations under air. (2004)
- Increasing Rates and Scope of Reactions (2003)
